CIRCADIAN CONTROL OF ALZHEIMER’S DISEASE IN DROSOPHILA MELANOGASTER
Home institution: Teesside University – UK (24 months)
Host institution: Bologna University – Italy (10 months)
PhD Enrolment #1: Teesside University - UK
PhD Enrolment #2: Bologna University – Italy
Supervisor #1: Tora Smulders-Srinivasan.
Supervisor #2: Manuela Bartolini
Intersectoral Secondment: BioTalentum – Hungary
Objectives: The School of Health and Life Sciences, Teesside University, is looking to appoint an Early-Stage Researcher (ESR) within a fixed term of 36 months to participate the Horizon Europe Marie Curie Doctoral Network TClock4AD project. This Research Fellow will be funded by UK Research and Innovation and carry out the following project: Circadian control of Alzheimer’s disease in Drosophila melanogaster. The major objective is to investigate the roles of circadian dysfunction in AD using Drosophila melanogaster. This will by done by: (a) using Drosophila clock mutations to analyse whether circadian dysfunction can play a pathogenic role in AD; (b) developing and validating a circadian dysfunction model of AD in Drosophila; (c) validating AD drugs candidates developed in TClock4AD in Drosophila AD or circadian AD models.
The doctoral candidate will work for two years in UK (Teesside University) and for 10 months in Bologna (University of Bologna) and will be involved in a 2-month secondment to a Hungarian company (BioTalentum Ltd).
Expected outcomes: The fellow is expected to generate breakthrough ideas in the assigned area of research, as well as to carry out research in line with the project plan. The fellow is also expected to contribute to dissemination and communication activities, besides actively collaborating within the TClock4AD network.
