DC11

Home institution: Wurzburg University – Germany (24 months)

Host institution: Lisbon University – Portugal (10 months)

PhD Enrolment #1: Wurzburg University - Germany

PhD Enrolment #2: Lisbon University – Portugal

Supervisor #1: Michael Decker

Supervisor #2: Rita Guedes

Intersectoral Secondment: Nostrum Biodiscovery – Spain

Objectives: The Pharmaceutical/Medicinal Chemistry Laboratory of the Institute of Pharmacy and Food Chemistry, Würzburg University, is looking to appoint a Marie Curie Research Fellow within a fixed term project dealing with the (computer-assisted) design, the organic synthesis, photophysical and pharmacological evaluation of photoswitchable GPCR ligands with special relevance in Alzheimer's disease, funded by the Horizon Europe project TClock4AD. This interdisciplinary work program is based on solid organic synthesis skills and medicinal chemistry knowledge.

The doctoral candidate will work for two years in Germany (Wurzburg University) and for 10 months in Portugal (Lisbon University) and will be involved in a 2-month secondment to a Spanish company (Nostrum Biodiscovery)

Expected outcomes: The fellow is expected to generate breakthrough ideas in the assigned area of research, as well as to carry out research in line with the project plan. The fellow is also expected to contribute to dissemination and communication activities, besides actively collaborating within the TClock4AD network. This DC will work closely with the Department of Pharmacology/Toxicology in Ghent, Belgium, and is expected to work for a period of 10 months in Lisbon, Portugal, to conduct molecular modelling studies to help designing the ligands to be synthesized.