Large-PFALs are size closed or semi-closed indoor cultivation systems with the size dedicated to the cultivation of plants greater than 30 m³, where the technologies used also grow as the dimension of the structure increases. Typically, many Large-PFALs use warehouses or other refurbished buildings instead of building new structures.

The characteristics of the Large-PFALS are the same as the Mini and Micro, with the addition that the production of plants on a commercial level is possible thanks to the larger dimensions, obtaining a greater yield.

AlmaVFarm - University of Bologna

AlmaVFarm is an experimental, demonstrative, educational Large-PFALs. Here, through the use of dimmable LED lights and the control and management of all environmental parameters (CO2, temperature, humidity, air control), hydroponic and aeroponic growing systems are implemented to have a fully-controlled plant production system. Moreover, nursery’s installations (for high plant density and characteristics suitable for the young seedlings, are also present. 

^{Kozai, Niu, Takagaki. (2019). Plant Factory. An Indoor Vertical Farming System for Efficient Quality Food Production. Academic Press.}