Publications

Pont C.,Ginex T.,Griñán-Ferré C.,Scheiner M.,Mattellone A.,Martínez N.,Arce E.M.,Soriano-Fernández Y.,Naldi M.,De Simone A.,Barenys M.,Gómez-Catalán J., Pérez B.,Sabate R.,Andrisano V.,Loza M.,Brea J.,Bartolini M.,Bolognesi M.L.,Decker M.,Pallàs M.,Luque F.J.,Muñoz-Torrero D. From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects. European Journal of Medicinal Chemistry, 2021, 225, 113779

Uliassi, E., de Oliveira, A.S., Nascente, L.C., Romeiro, L.A.S., Bolognesi, M.L. Cashew nut shell liquid (Cnsl) as a source of drugs for alzheimer’s disease. Molecules, 2021, 26(18), 5441

Dolci, L. S.; Perone, R. C.; Di Gesù, R.; Kurakula, M.; Gualandi, C.; Zironi, E.; Gazzotti, T.; Tondo, M. T.; Pagliuca, G.; Gostynska, N.; Baldassarro, V. A.; Cescatti, M.; Giardino, L.; Focarete, M. L.; Calzà, L.; Passerini, N.; Bolognesi, M. L., Design and In Vitro Study of a Dual Drug-Loaded Delivery System Produced by Electrospinning for the Treatment of Acute Injuries of the Central Nervous System. Pharmaceutics 2021, 13 (6).

Ramos, G.; de Oliveira, A.; Bartolini, M.; Naldi, M.; Liparulo, I.; Bergamini, C.; Uliassi, E.; Wu, L.; Fraser, P.; Abreu, M.; Kiametis, A.; Gargano, R.; Silveira, E.; Brand, G.; Prchal, L.; Soukup, O.; Korabecny, J.; Bolognesi, M.; Romeiro, L., Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties. Rsc Medicinal Chemistry 2021, 12 (7), 1154-1163.

Rossi, M.; Freschi, M.; de Camargo Nascente, L.; Salerno, A.; de Melo Viana Teixeira, S.; Nachon, F.; Chantegreil, F.; Soukup, O.; Prchal, L.; Malaguti, M.; Bergamini, C.; Bartolini, M.; Angeloni, C.; Hrelia, S.; Soares Romeiro, L. A.; Bolognesi, M. L., Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. J Med Chem 2021, 64 (8), 4972-4990.

Gorecki, L.; Uliassi, E.; Bartolini, M.; Janockova, J.; Hrabinova, M.; Hepnarova, V.; Prchal, L.; Muckova, L.; Pejchal, J.; Karasova, J. Z.; Mezeiova, E.; Benkova, M.; Kobrlova, T.; Soukup, O.; Petralla, S.; Monti, B.; Korabecny, J.; Bolognesi, M. L., Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease. ACS Chem Neurosci 2021, 12 (9), 1698-1715.

González-González, A.; Vazquez-Jimenez, L. K.; Paz-González, A. D.; Bolognesi, M. L.; Rivera, G., Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents. Curr Med Chem 2021.

Albertini, C.; Naldi, M.; Petralla, S.; Strocchi, S.; Grifoni, D.; Monti, B.; Bartolini, M.; Bolognesi, M. L., From Combinations to Single-Molecule Polypharmacology-Cromolyn-Ibuprofen Conjugates for Alzheimer's Disease. Molecules 2021, 26 (4).

Perone R, Albertini C, Uliassi E, Di Pietri F, de Sena Murteira Pinheiro P, Petralla S, Rizzardi N, Fato R, Pulkrabkova L, Soukup O, Tramarin A, Bartolini M, Bolognesi M.L.Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy. ChemMedChem 16, 1, 2021, 187-198

Rossi M, Petralla S, Protti M, Baiula M, Kobrlova T, Soukup O, Spampinato S.M, Mercolini L, Monti B, Bolognesi M.L. α-Linolenic Acid-Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis. ACS Med Chem Letters, 2020, 11(12), pp. 2406–2413

Al-Tel T.H, Srinivasulu V, Ramanathan M, Soares N.C, Sebastian A, Bolognesi M.L, Abu-Yousef I.A, Majdalawieh A. Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures. Org Biomol Chem 2020, 18 (42), 8526-8571.

Rodrigues, D. A.; Pinheiro, P. S. M.; Sagrillo, F. S.; Bolognesi, M. L.; Fraga, C. A. M., Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities. Med Res Rev 2020, 40 (6), 2177-2211.

Linciano P, Cullia G, Borsari C, Santucci M, Ferrari S, Witt G, Gul S, Kuzikov M, Ellinger B, Santarém N, Cordeiro da Silva A, Conti P, Bolognesi ML, Roberti M, Prati F, Bartoccini F, Retini M, Piersanti G, Cavalli A, Goldoni L, Bertozzi SM, Bertozzi F, Brambilla E, Rizzo V, Piomelli D, Pinto A, Bandiera T, Costi MP. Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign. Eur J Med Chem. 2020 Mar 1;189:112047.

Bolognesi ML, Ganamet KL, Liu H, Poulsen SA, Georg GI, Wang S. Women in Medicinal Chemistry: Ad Maiora! J Med Chem. 2020 Mar 12;63(5):1777-1778.

Huryn DM, Bolognesi ML. A Different Kind of Medicinal Chemistry Toolbox. ACS Med Chem Lett. 2020 Mar 12;11(3):245-248.

Marques CS, López Ó, Bagetta D, Carreiro EP, Petralla S, Bartolini M, Hoffmann M, Alcaro S, Monti B, Bolognesi ML, Decker M, Fernández-Bolaños JG, Burke AJ. N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study. Bioorg Chem. 2020 May;98:103753.

Zaccagnini L, Rossetti G, Tran TH, Salzano G, Gandini A, Colini Baldeschi A, Bolognesi ML, Carloni P, Legname G. In silico/in vitro screening and hit evaluation identified new phenothiazine anti-prion derivatives. Eur J Med Chem. 2020 Jun 15;196:112295.

Uliassi E, Peña-Altamira LE, Morales AV, Massenzio F, Petralla S, Rossi M, Roberti M, Martinez Gonzalez L, Martinez A, Monti B, Bolognesi ML. A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential. ACS Chem Neurosci. 2019 Jan 16;10(1):279-294.

Cerone M, Uliassi E, Prati F, Ebiloma GU, Lemgruber L, Bergamini C, Watson DG, de A M Ferreira T, Roth Cardoso GSH, Soares Romeiro LA, de Koning HP, Bolognesi ML. Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei. ChemMedChem. 2019 Mar 22;14(6):621-635.

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S. Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform. SLAS Discov. 2019 Mar;24(3):346-361.

Alcaro S, Bolognesi ML, García-Sosa AT, Rapposelli S. Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation. Front Chem. 2019 Feb 18;7:71. doi: 10.3389/fchem.2019.00071. eCollection 2019.

Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K. Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. Eur J Med Chem.

Bolognesi ML. Harnessing Polypharmacology with Medicinal Chemistry. ACS Med Chem Lett. 2019 Feb 15;10(3):273-275.

Staderini M, Piquero M, Abengózar MÁ, Nachér-Vázquez M, Romanelli G, López-Alvarado P, Rivas L, Bolognesi ML, Menéndez JC. Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold. Eur J Med Chem. 2019 Jun 1;171:38-53.

Bolognesi ML, Ganamet KL, Liu H, Poulsen SA, Georg GI, Wang S. Women in Medicinal Chemistry Special Issue Call for Papers. J Med Chem. 2019 Apr 25;62(8):3783.

Soares Romeiro LA, da Costa Nunes JL, de Oliveira Miranda C, Simões Heyn Roth Cardoso G, de Oliveira AS, Gandini A, Kobrlova T, Soukup O, Rossi M, Senger J, Jung M, Gervasoni S, Vistoli G, Petralla S, Massenzio F, Monti B, Bolognesi ML. Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer's Disease. ACS Med Chem Lett. 2019 Mar 29;10(4):671-676.

Ivasiv V, Albertini C, Gonçalves AE, Rossi M, Bolognesi ML. Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases. Curr Top Med Chem. 2019;19(19):1694-1711.

Roldán-Peña JM, Romero-Real V, Hicke J, Maya I, Franconetti A, Lagunes I, Padrón JM, Petralla S, Poeta E, Naldi M, Bartolini M, Monti B, Bolognesi ML, López Ó, Fernández-Bolaños JG. Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors. Eur J Med Chem. 2019 Nov 1;181:111550.

Moda F, Bolognesi ML, Legname G. Novel screening approaches for human prion diseases drug discovery. Expert Opin Drug Discov. 2019 Oct;14(10):983-993.

Lanthier C, Payan H, Liparulo I, Hatat B, Lecoutey C, Since M, Davis A, Bergamini C, Claeysen S, Dallemagne P, Bolognesi ML, Rochais C. Novel multi target-directed ligands targeting 5-HT(4) receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease. Eur J Med Chem. 2019 Nov 15;182:111596.

Gandini A, Bartolini M, Tedesco D, Martinez-Gonzalez L, Roca C, Campillo NE, Zaldivar-Diez J, Perez C, Zuccheri G, Miti A, Feoli A, Castellano S, Petralla S, Monti B, Rossi M, Moda F, Legname G, Martinez A, Bolognesi ML. Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors. J Med Chem. 2018 Sep 13;61(17):7640-7656.

Elisi GM, Santucci M, D'Arca D, Lauriola A, Marverti G, Losi L, Scalvini L, Bolognesi ML, Mor M, Costi MP. Repurposing of Drugs Targeting YAP-TEAD Functions. Cancers (Basel). 2018 Sep 14;10(9).

Ramsay RR, Popovic-Nikolic MR, Nikolic K, Uliassi E, Bolognesi ML. A perspective on multi-target drug discovery and design for complex diseases. Clin Transl Med. 2018 Jan 17;7(1):3.

Uliassi E, Piazzi L, Belluti F, Mazzanti A, Kaiser M, Brun R, Moraes CB, Freitas-Junior LH, Gul S, Kuzikov M, Ellinger B, Borsari C, Costi MP, Bolognesi ML. Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections. ChemMedChem. 2018 Apr 6;13(7):678-683.

Ortuso F, Bagetta D, Maruca A, Talarico C, Bolognesi ML, Haider N, Borges F, Bryant S, Langer T, Senderowitz H, Alcaro S. The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing. Front Chem. 2018 Apr 19;6:130.

Chioua M, Buzzi E, Moraleda I, Iriepa I, Maj M, Wnorowski A, Giovannini C, Tramarin A, Portali F, Ismaili L, López-Alvarado P, Bolognesi ML, Jóźwiak K, Menéndez JC, Marco-Contelles J, Bartolini M. Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease. Eur J Med Chem. 2018 Jul 15;155:839-846.