Core-Shell Nanostructures for Drug Delivery and Theranostics

1st Edition - Challenges, Strategies and Prospects for Novel Carrier Systems

Editors: Maria Letizia Focarete Anna Tampieri

2018, Woodhead Publishing eBook ISBN: 9780081021996; Paperback ISBN: 9780081021989


Filtering Media by Electrospinning

Next Generation Membranes for Separation Applications

Focarete Maria Letizia, Gualandi Chiara, Ramakrishna Seeram (Eds.)

2018, Springer ISBN 978-3-319-78162-4




D. Bonincontro, F. Fraschetti, C. Squarzoni, L. Mazzocchetti, E. Maccaferri, L. Giorgini, A. Zucchelli, C. Gualandi, M. L. Focarete, S. Albonetti, Pd/Au Based Catalyst Immobilization in Polymeric Nanofibrous Membranes via Electrospinning for the Selective Oxidation of 5-Hydroxymethylfurfural, Processes 2020, 8, 45. Abstract

A. Liguori, C. Gualandi, M. L. Focarete, F. Biscarini, M. Bianchi, The pulsed electron deposition technique for biomedical applications: a review, Coatings 2020, 10, 16. Abstract

R. Di Gesù, C. Gualandi, A. Zucchelli, A. Liguori, L. Paltrinieri, M. L. Focarete. Biodegradable electrospun fibers enriched with struvite crystal seeds for the recovery of phosphorous and nitrogen. European Polymer Journal 2020, 122, 109389. Abstract

A. Terella, F. De Giorgio, M. Rahmanipour, L. Malavolta, E. Paolasini, D. Fabiani, M. L. Focarete, C. Arbizzani, Functional separators for the batteries of the futureJournal of Power Sources 2020, 449, 227556. Abstract


A. Liguori, J. Uranga, S. Panzavolta, P. Guerrero, K. de la Caba, M. L. Focarete, Electrospinning of fish gelatin solution containing citric acid: An environmentally friendly approach to prepare crosslinked gelatin fibers. Materials, 2019, 12, 2808. Abstract

A. Sensini, C. Gualandi, M. L. Focarete, J. Belcari, A. Zucchelli, L. Boyle, G. C. Reilly, A. P. Kao , G. Tozzi, L. Cristofolini, Multiscale hierarchical bioresorbable scaffolds for the regeneration of tendons and ligamentsBiofabrication 2019, 11, 035026. Abstract

A. Sensini, C. Gotti, J. Belcari, A. Zucchelli, M. L. Focarete, C. Gualandi, I. Todaro, A. P. Kao, G. Tozzi, L. Cristofolini, Morphologically bioinspired hierarchical nylon 6,6 electrospun assembly recreating the structure and performance of tendons and ligaments, Medical Engineering and Physics 2019, 71, 79-90. Abstract



A. Sensini, C. Gualandi, A. Zucchelli, L. A. Boyle, A. P. Kao, G. C. Reilly, G. Tozzi, L. Cristofolini, M. L. Focarete. Tendon fascicle-inspired nanofibrous scaffold of polylactic acid/collagen with enhanced 3D-structure and biomechanical properties. Scientific Reports, 2018, 8, Article ID 17167. Abstract

N. Bloise, E. Berardi, C. Gualandi, E. Zaghi, M. Gigli, R. Duelen, G. Ceccarelli, E. E. Cortesi, D. Costamagna, G. Bruni, N. Lotti, M. L. Focarete, L. Visai, M. Sampaolesi. Ether-oxygen containing electrospun microfibrous and sub-microfibrous scaffolds based on poly(butylene 1,4-cyclohexanedicarboxylate) for skeletal muscle tissue engineering. International Journal of Molecular Science, 2018, 19, Article ID 3212. Abstract

M. Raisch, D. Genovese, N. Zaccheroni, S. B. Schmidt, M. L. Focarete, M. Sommer, C. Gualandi. Highly sensitive, anisotropic, and reversible stress/strain‐sensors from mechanochromic nanofiber composites. Advanced Materials, 2018, 30, Article ID 1802813. Abstract

R. Di Gesù, A. Merlettini, C. Gualandi, M.L. Focarete, Advances in multidrug delivery from electrospun nanomaterials, in “Core-Shell Nanostructures for Drug Delivery and Theranostics”, A. Tampieri, M.L. Focarete Editors, 2018, Pages 405-430 Woodhead Publishing, ISBN: 9780081021996 (online); ISBN: 9780081021989 (print). Abstract

A. Sensini, L. Cristofolini, M.L. Focarete, J. Belcari, A. Zucchelli, P. Kao, G. Tozzi. High-resolution x-ray tomographic morphological characterisation of electrospun nanofibrous bundles for tendon and ligament regeneration and replacement. Journal of Microscopy, 2018, 272, 196–206. Abstract

I.R. Khalil, M.P. Khechara, S. Kurusamy, A.L. Armesilla, A. Gupta, B. Mendrek, T. Khalaf, M. Scandola, M.L. Focarete, M. Kowalczuk, I. Radecka. Poly-Gamma-Glutamic Acid (γ-PGA)-Based Encapsulation of Adenovirus to Evade Neutralizing Antibodies. Molecules, 2018, 23, Article ID 2565. Abstract

E.M. Chen, A.R. Quijano, Y.-E. Seo, C. Jackson, A.D. Josowitz, S. Noorbakhsh, A. Merlettini, R.K. Sundaram, M.L. Focarete, Z. Jiang, R.S. Bindra, W.M. Saltzman. Biodegradable PEG-poly(w-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors. Biomaterials, 2018, 178, 193-203. Abstract

A. Bandiera, S. Passamonti, L.S. Dolci, M.L. Focarete. Composite of Elastin-Based Matrix and Electrospun Poly(L-Lactic Acid) Fibers: A Potential Smart Drug Delivery System. Front. Bioeng. Biotechnol., 2018



A. Merlettini, M. Gigli, M. Ramella, C. Gualandi, M. Soccio, F. Boccafoschi, A. Munari, N. Lotti, M. L. Focarete. Thermal annealing to modulate the shape memory behavior of a biobased and biocompatible triblock copolymer scaffold in the human body temperature range. Biomacromolecules, 2017, 18, 2499-2508. Abstract

A. Sensini, C. Gualandi, L. Cristofolini, G. Tozzi, M. Dicarlo, G. Teti, M. Mattioli-Belmonte, M. L. Focarete. Biofabrication of bundles of poly(lactic acid)-collagen blends mimicking the fascicles of the human Achille tendon. Biofabrication, 2017, 9, Article ID 015025. Abstract

S. Pandini, S. Agnelli, A. Merlettini, F. Chiellini, C. Gualandi, K. Paderni, M. L. Focarete, M. Messori, M. Toselli. Mutifunctional electrospun non-woven mats with two-way shape memory behavior prepared from sol-gel crosslinked poly(ε-caprolactone). Macromolecular Materials and Engineering, 2017 Article ID: 1600519 . Abstract

A. Fiorani, F. Totsingan, A. Pollicino, Y. Peng, M.L. Focarete, R.A. Gross, M. Scandola. Peptide Modified Electrospun Glycopolymer FibersMacromolecular Bioscience, 2017, 17, 1 - 12. Abstract

A. La Monaca,  F. De Giorgio, M.L. Focarete, D. Fabiani, M. Zaccaria, C. Arbizzani. Polyvinylidene difluoride-polyethyleneoxide blends for electrospun separators in Li-Ion batteries. Journal of The  Electrochemical Society, 2017, 164, A6431 - A6439. Abstract



A. Liguori, A. Bigi, V. Colombo, M. L. Focarete, M. Gherardi, C. Gualandi, M. C. Oleari, S. Panzavolta. Atmospheric pressure non-equilibrium plasma as a green tool to crosslink gelatin nanofibers. Scientific Reports, 2016, 6, Article ID 38542. Abstract

S. Panzavolta, C. Gualandi, A. Fiorani, B. Bracci, M. L. Focarete, A. Bigi. Fast coprecipitation of calcium phosphate nanoparticles inside gelatin nanofibers by tricoaxial electrospinning. Journal of Nanomaterials, 2016, Article ID 4235235. Abstract

C. Gualandi, N. Bloise, N. Mauro, P. Ferruti, A. Manfredi, M. Sampaolesi, A. Liguori, R. Laurita, M. Gherardi, V. Colombo, L. Visai, M.L. Focarete, E. Ranucci. Poly- L-lactic acid nanofiber–Polyamidoamine hydrogel composites: preparation, properties, and preliminary evaluation as scaffolds for human pluripotent stem cell culturing. Macromolecular Bioscience, 2016, 16, 1533-1544. Abstract

V. A. Baldassarro, L. S. Dolci, C. Mangano, L. Giardino, C. Gualandi, M. L. Focarete, L. Calzà. In vitro testing of biomaterials for neural repair: focus on cellular systems and high-content analysis. BioResearch Open Access, 2016, 5, 201-21. Abstract

A. Merlettini, S. Pandini, S. Agnelli, C. Gualandi, K. Paderni, M. Messori, M. Toselli, M. L. Focarete. Facile fabrication of shape memory poly(ε-caprolactone) non-woven mat by combining electrospinning and sol–gel reaction. RSC Advanced 2016, 6, 43964-43974. Abstract

C. Gualandi, P. Torricelli, S. Panzavolta, S. Pagani, M. L. Focarete, A. Bigi. An innovative co-axial system to electrospin in situ crosslinked gelatin nanofibers. Biomedical Materials, 2016, 11, 025007. Abstract

H. Chen, M. Gigli, C. Gualandi, R. Truckenmuller, C. Van Blitterswijk, N. Lotti, A. Munari, M. L. Focarete, L. Moroni. Tailoring chemical and physical properties of fibrous scaffolds from block copolyesters containing ether and thio-ether linkages for skeletal differentiation of human mesenchymal stromal cells. Biomaterials, 2016, 76, 261-272. Abstract

L. S. Dolci, A. Liguori, A. Merlettini, L. Calzà, M. Castellucci, M. Gherardi, V. Colombo, M. L. Focarete. Antibody immobilization on poly(L-lactic acid) nanofibers advantageously carried out by means of a non-equilibrium atmospheric plasma process. Journal of Physics D: Applied Physics, 2016, 49, 274003 - 274011. Abstract

M. L. Focarete, C. Gualandi. Cell delivery for regenerative medicine by using bioresorbable polymers. Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine, Duxford, Elsevier, 2016, 365 - 389. Book Chapter

A. Liguori, E. Traldi, E. Toccaceli, R. Laurita, A. Pollicino, M. L. Focarete, V. Colombo, M. Gherardi. Co-Deposition of Plasma-Polymerized Polyacrylic Acid and Silver Nanoparticles for the Production of Nanocomposite Coatings Using a Non-Equilibrium Atmospheric Pressure Plasma Jet. Plasma Processes and Polymers, 2016, 13, 623 - 632. Abstract 

A. Liguori, A. Pollicino, A. Stancampiano, F. Tarterini, M. L. Focarete, V. Colombo, M. Gherardi. Deposition of Plasma-Polymerized Polyacrylic Acid Coatings by a Non-Equilibrium Atmospheric Pressure Nanopulsed Plasma Jet. Plasma Processes and Polymers, 2016, 13, 375 - 386. Abstract

A. La Monaca, C. Arbizzani, F. De Giorgio, M. L. Focarete, D. Fabiani, M. Zaccaria. Electrospun membranes based on PVdF-PEO blends for lithium batteries. Ecs Transactions, 2016, 73, 75 - 81. Abstract

R. Laurita, M. Zaccaria, M. Gherardi, D. Fabiani, A. Merlettini, A. Pollicino, M. L. Focarete, V. Colombo. Plasma Processing of Electrospun Li-Ion Battery Separators to Improve Electrolyte UptakePlasma Processes and Polymers, 2016, 13, 124 - 133. Abstract

L. Milli, N. Zanna, A. Merlettini, M. Di Giosia, M. Calvaresi, M. L. Focarete, C. Tomasini. Pseudopeptide-Based Hydrogels Trapping Methylene Blue and Eosin Y. Chemistry-A European Journal, 2016, 22, 12106 - 12112. Abstract

S. Pandini, S. Agnelli, A. Merlettini, C. Gualandi, M. L. Focarete, K. Paderni, M. Messori, M. Toselli. Two-Way Shape Memory Behavior of Electrospun Non-Woven Mats Prepared from Sol-Gel Crosslinked Poly(ε-Caprolactone). 7th Forum on New Materials - Part A, Stäfa, Trans Tech Publications Ltd, 2016, 100 - 105 (ADVANCES IN SCIENCE AND TECHNOLOGY). Book Chapter



A. Buzarovska, C. Gualandi, A. Parrilli, M. Scandola. Effect of TiO2 nanoparticle loading on Poly(L-lactic acid) porous scaffolds fabricated by TIPS. Composites Part B, 2015, 81, 189-195. Abstract

G. Totaro, L. Paltrinieri, G. Mazzola, M. Vannini, L. Sisti, C. Gualandi, A. Ballestrazzi, S. Valeri, A. Pollicino, A. Celli, D. Di Gioia, M. L. Focarete. Electrospun Fibers Containing Bio-Based Ricinoleic Acid: Effect of Amount and Distribution of Ricinoleic Acid Unit on Antibacterial Properties. Macromolecular Materials and Engineering, 2015, 300, 1085-1095. Abstract

A. Liguori, L. Paltrinieri, A. Stancampiano, C. Gualandi, M. Gherardi, V. Colombo, M.L. Focarete. Solid-State Crosslinking of Polysaccharide Electrospun Fibers by Atmospheric pressure Non-Equilibrium Plasma: A Novel Straightforward Approach. Plasma Processes and Polymers, 2015, 12, 1195-1199. Abstract

M. Gazzano, C. Gualandi, A. Zucchelli, T. Sui, A.M. Korsunsky, C. Reinhard, M.L. Focarete. Structure-morphology correlation in electrospun fibers of semicrystalline polymers by simultaneous synchrotron SAXS-WAXDPolymer, 2015, 63, 154-163. Abstract

    M. Zaccaria, D. Fabiani, G. Cannucciari, C. Gualandi, M. L. Focarete, C. Arbizzani, F. De Giorgio, M. Mastragostino. Effect of Silica and Tin Oxide Nanoparticles on Properties of Nanofibrous Electrospun SeparatorsJournal of The Electrochemical Society, 2015, 162, A915-A920. Abstract

      C. Gualandi, A. Celli, A. Zucchelli, M.L. Focarete. Nanohybrid Materials by ElectrospinningAdvances in Polymer Science, 2015, 267, 87-142. Abstract

      S. Alessi, M. Di Filippo, C. Dispenza, M.L. Focarete, C. Gualandi, R. Palazzetti, G. Pitarresi, A. Zucchelli. Effects of nylon 6,6 nanofibrous mats on thermal properties and delamination behavior of high performance CFRP laminatesPolymer Composites, 2015, 36, 1303-1313. Abstract

      N. Zanna, A. Merlettini, G. Tatulli, L. Milli, M. L. Focarete, C. Tomasini. Hydrogelation induced by Fmoc-protected peptidomimetics. Langmuir, 2015, 31, 12240-12250, ISSN: 0743-7463, doi: 10.1021/acs.langmuir.5b02780. Abstract



      A. Fiorani, C. Gualandi, S. Panseri, M. Montesi, M. Marcacci, M. L. Focarete, A. Bigi. Comparative performance of collagen nanofibers electrospun from different solvents and stabilized by different crosslinkersJournal of Materials Science: Materials in Medicine, 2014, 25, 2313-2321. Abstract

      P. Torricelli, M. Gioffrè, A. Fiorani, S. Panzavolta, C. Gualandi, M. Fini, M. L. Focarete, A. Bigi. Co-electrospun gelatin-poly(L-lactic acid) scaffolds: Modulation of mechanical properties and chondrocyte response as a function of compositionMaterials Science and Engineering C, 2014, 36, 130-138. Abstract

      S. Panzavolta, B. Bracci, C. Gualandi, M. L. Focarete, E. Treossi, K. Kouroupis-Agalou, K. Rubini, F. Bosia, L. Brely, N. M. Pugno, V. Palermo, A. Bigi. Structural reinforcement and failure analysis in composite nanofibers of graphene oxide and gelatinCarbon, 2014, 78, 566-577. Abstract

      V. Colombo, D. Fabiani, M. L. Focarete, M. Gherardi, C. Gualandi, R. Laurita, M. Zaccaria. Atmospheric pressure non-equilibrium plasma treatment to improve the electrospinnability of poly(L-lactic acid) polymeric solutionPlasma Processes and Polymers, 2014, 11, 247-255. Abstract

      M. Alessandri, G. Lizzo, C. Gualandi, C. Mangano, A. Giuliani, M. L. Focarete, L. Calzà. Influence of biological matrix and artificial electrospun scaffolds on proliferation, differentiation and trophic factor synthesis of rat embryonic stem cells. Original Research Article, Matrix Biology, 2014, 33, 68-76. Abstract

      L. S. Dolci, S. D. Quiroga, M. Gherardi, R. Laurita, A. Liguori, P. Sanibondi, A. Fiorani, L. Calza', V. Colombo, M. L. Focarete. Carboxyl Surface Functionalization of Poly(L-lactic acid) Electrospun Nanofibers through Atmospheric Non-Thermal Plasma Affects Fibroblast Morphology. Plasma Processes and Polymers, 2014,11, 203-213, ISSN: 1612-8850, doi: 10.1002/ppap.201300104. Abstract

      L. Martino, M. V. Cruz, A. Scoma, F. Freitas, L. Bertin, M. Scandola, M. A. M. Reis. Recovery of amorphous polyhydroxybutyrate Granules from Cupriavidus necator cells grown on used cooking oilInt. J. Biol. Macromol., 2014 , 71, 117-123. Abstract

      I. Voevodina, M. Scandola, J. Zhang, Z. Jiang. Exploring the solid state properties of enzymatic poly(amine-co-ester) terpolymers to expand their applications in gene transfectionRSC Adv., 2014, 4 (18), 8953 – 8961. Abstract

      L.Martino, L. Basilissi, H. Farina, M. A. Ortenzi, E. Zini, G. Di Silvestro, M.Scandola. Bio-based polyamide 11: Synthesis, rheology and solid-state properties of star structures. European Polymer Journal, 2014, 59, 69–77. Abstract

      M. Villano, F. Valentino, A. Barbetta, L. Martino, M. Scandola, M. Majone. Polyhydroxyalkanoates production with mixed microbial cultures: from culture selection to polymer recovery in a high-rate continuous process. New Biotechnology, 2014, 31, 289–296. Abstract