Stoolman JS, Porcelli AM, Martínez-Reyes I. Editorial: Mitochondria as a hub in cellular signaling. Front Cell Dev Biol. 2022 Aug 15;10:981464. doi: 10.3389/fcell.2022.981464.
De Luise M., Sollazzo M., Lama E., Coadă C.A., Bressi L., Iorio M., Cavina B., D'Angelo L., Milioni S., Marchio L., Miglietta S., Coluccelli S., Tedesco G., Ghelli A., Lemma S., Perrone A.M., Kurelac I., Iommarini L., Porcelli A.M., Gasparre G.Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer. Scientific Reports 2022 doi: 10.1038/s41598-022-11620-y.
Firrincieli A., Zannoni D., Donini E., Dostálová H., Rädisch R., Iommarini L., Turner R.J., Busche T., Pátek M., Cappelletti M. Transcriptomic Analysis of the Dual Response of Rhodococcus aetherivorans BCP1 to Inorganic Arsenic Oxyanions Applied and Environmental Microbiology 2022 doi:10.1128/aem.02209-21
Musiani F., Rigobello L., Iommarini L., Carelli V., Esposti M.D., Ghelli A.M. New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/MT-ND4 Mutation Associated with Leber’s Hereditary Optic Neuropathy Molecules 2022 doi:10.3390/molecules27041341
D'Angelo L., Astro E., De Luise M., Kurelac I., Umesh-Ganesh N., Ding S., Fearnley I.M., Gasparre G., Zeviani M., Porcelli A.M., Fernandez-Vizarra E., Iommarini L. NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate Cell Reports 2021 doi:10.1016/j.celrep.2021.109002
De Luise M., Iommarini L., Marchio L., Tedesco G., Coadă C.A., Repaci A., Turchetti D., Tardio M.L., Salfi N., Pagotto U., Kurelac I., Porcelli A.M., Gasparre G. Pathogenic mitochondrial DNA mutation load inversely correlates with malignant features in familial oncocytic parathyroid tumors associated with hyperparathyroidism-jaw tumor syndrome Cells 2021 doi:10.3390/cells10112920
Iorio M., Ganesh N.U., De Luise M., Porcelli A.M., Gasparre G., Kurelac I. The neglected liaison: Targeting cancer cell metabolic reprogramming modifies the composition of non‐malignant populations of the tumor microenvironment Cancers 2021 doi:10.3390/cancers13215447
Páleníková P., Harbour M.E., Prodi F., Minczuk M., Zeviani M., Ghelli A., Fernández-Vizarra E. Duplexing complexome profiling with SILAC to study human respiratory chain assembly defects Biochimica et Biophysica Acta - Bioenergetics 2021 doi:10.1016/j.bbabio.2021.148395
Perrone A.M., Ravegnini G., Miglietta S., Argnani L., Ferioli M., De Crescenzo E., Tesei M., Di Stanislao M., Girolimetti G., Gasparre G., Porcelli A.M., De Terlizzi F., Zamagni C., Morganti A.G., De Iaco P. Electrochemotherapy in vulvar cancer and cisplatin combined with electroporation. Systematic review and in vitro studies Cancers 2021 doi:10.3390/cancers13091993
Rugolo M., Zanna C., Ghelli A.M. Organization of the respiratory supercomplexes in cells with defective complex III: Structural features and metabolic consequences Life 2021 doi:10.3390/life11040351
Sollazzo M., De Luise M., Lemma S., Bressi L., Iorio M., Miglietta S., Milioni S., Kurelac I., Iommarini L., Gasparre G., Porcelli A.M. Respiratory Complex I dysfunction in cancer: from a maze of cellular adaptive responses to potential therapeutic strategies FEBS Journal 2021 doi:10.1111/febs.16218
Abla H., Sollazzo M., Gasparre G., Iommarini L., Porcelli A.M. The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit? Seminars in Cell and Developmental Biology 2020 doi:10.1016/j.semcdb.2019.05.031
Aleo S.J., Del Dotto V., Fogazza M., Maresca A., Lodi T., Goffrini P., Ghelli A., Rugolo M., Carelli V., Baruffini E., Zanna C. Drug repositioning as a therapeutic strategy for neurodegenerations associated with OPA1 mutations Human Molecular Genetics 2020 doi:10.1093/hmg/ddaa244
Bisag A., Bucci C., Coluccelli S., Girolimetti G., Laurita R., De Iaco P., Perrone A.M., Gherardi M., Marchio L., Porcelli A.M., Colombo V., Gasparre G. Plasma-activated ringer’s lactate solution displays a selective cytotoxic effect on ovarian cancer cells Cancers 2020 doi:10.3390/cancers12020476
Chao De La Barca J.M., Fogazza M., Rugolo M., Chupin S., Del Dotto V., Ghelli A.M., Carelli V., Simard G., Procaccio V., Bonneau D., Lenaers G., Reynier P., Zanna C. Metabolomics hallmarks OPA1 variants correlating with their in vitro phenotype and predicting clinical severity Human Molecular Genetics 2020 doi:10.1093/hmg/ddaa047
Gasparre G., Porcelli A.M. The Human Mitochondrial Genome: From Basic Biology to Disease The Human Mitochondrial Genome: From Basic Biology to Disease 2020 doi:10.1016/B978-0-12-819656-4.00021-8
Girolimetti G., De Luise M., Porcelli A.M., Gasparre G., Kurelac I. mtDNA mutations in cancer The Human Mitochondrial Genome: From Basic Biology to Disease 2020 doi:10.1016/B978-0-12-819656-4.00017-6
Iommarini L., Ghelli A., Diaz F. Methods and models for functional studies on mtDNA mutations The Human Mitochondrial Genome: From Basic Biology to Disease 2020 doi:10.1016/B978-0-12-819656-4.00013-9
Kurelac I., Umesh Ganesh N., Iorio M., Porcelli A.M., Gasparre G. The multifaceted effects of metformin on tumor microenvironment Seminars in Cell and Developmental Biology 2020 doi:10.1016/j.semcdb.2019.05.010
Perli E., Pisano A., Pignataro M.G., Campese A.F., Pelullo M., Genovese I., de Turris V., Ghelli A.M., Cerbelli B., Giordano C., Colotti G., Morea V., d'Amati G. Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects FASEB Journal 2020 doi:10.1096/fj.201903270R
Tropeano C.V., Aleo S.J., Zanna C., Roberti M., Scandiffio L., Loguercio Polosa P., Fiori J., Porru E., Roda A., Carelli V., Steimle S., Daldal F., Rugolo M., Ghelli A. Fine-tuning of the respiratory complexes stability and supercomplexes assembly in cells defective of complex III Biochimica et Biophysica Acta - Bioenergetics 2020 doi:10.1016/j.bbabio.2019.148133
De Luise M., Guarnieri V., Ceccarelli C., D’Agruma L., Porcelli A.M., Gasparre G. A nonsense mitochondrial DNA mutation associates with dysfunction of HIF1α in a von Hippel-Lindau renal oncocytoma Oxidative Medicine and Cellular Longevity 2019 doi:10.1155/2019/8069583
Kurelac I., Abarrategi A., Ragazzi M., Iommarini L., Ganesh N.U., Snoeks T., Bonnet D., Porcelli A.M., Malanchi I., Gasparre G. A humanized bone niche model reveals bone tissue preservation upon targeting mitochondrial complex i in pseudo-orthotopic osteosarcoma Journal of Clinical Medicine 2019 doi:10.3390/jcm8122184
Kurelac I., Iommarini L., Vatrinet R., Amato L.B., De Luise M., Leone G., Girolimetti G., Umesh Ganesh N., Bridgeman V.L., Ombrato L., Columbaro M., Ragazzi M., Gibellini L., Sollazzo M., Feichtinger R.G., Vidali S., Baldassarre M., Foriel S., Vidone M., Cossarizza A., Grifoni D., Kofler B., Malanchi I., Porcelli A.M., Gasparre G. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses Nature Communications 2019 doi:10.1038/s41467-019-08839-1
Locatelli A., Iommarini L., Graziadio A., Leoni A., Porcelli A.M., Iotti S., Malucelli E., Francia F., Venturoli G., Farruggia G. Dansyl acetyl trehalose: A novel tool to investigate the cellular fate of trehalose RSC Advances 2019 doi:10.1039/c9ra01800j
Malferrari M., Ghelli A., Roggiani F., Valenti G., Paolucci F., Rugolo M., Rapino S. Reactive Oxygen Species Produced by Mutated Mitochondrial Respiratory Chains of Entire Cells Monitored Using Modified Microelectrodes ChemElectroChem 2019 doi:10.1002/celc.201801424
Mancini C., Hoxha E., Iommarini L., Brussino A., Richter U., Montarolo F., Cagnoli C., Parolisi R., Gondor Morosini D.I., Nicolò V., Maltecca F., Muratori L., Ronchi G., Geuna S., Arnaboldi F., Donetti E., Giorgio E., Cavalieri S., Di Gregorio E., Pozzi E., Ferrero M., Riberi E., Casari G., Altruda F., Turco E., Gasparre G., Battersby B.J., Porcelli A.M., Ferrero E., Brusco A., Tempia F. Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity Neurobiology of Disease 2019 doi:10.1016/j.nbd.2018.10.018
Perrone A.M., Dondi G., Lima G.M., Castellucci P., Tesei M., Coluccelli S., Gasparre G., Porcelli A.M., Nanni C., Fanti S., De Iaco P. Potential prognostic role of18 F-FDG PET/CT in invasive epithelial Ovarian cancer relapse. A preliminary study Cancers 2019 doi:10.3390/cancers11050713
Vidali S., Aminzadeh-Gohari S., Vatrinet R., Iommarini L., Porcelli A.M., Kofler B., Feichtinger R.G. Lithium and not acetoacetate influences the growth of cells treated with lithium acetoacetate International Journal of Molecular Sciences 2019 doi:10.3390/ijms20123104
Caporali L., Iommarini L., La Morgia C., Olivieri A., Achilli A., Maresca A., Valentino M.L., Capristo M., Tagliavini F., Del Dotto V., Zanna C., Liguori R., Barboni P., Carbonelli M., Cocetta V., Montopoli M., Martinuzzi A., Cenacchi G., De Michele G., Testa F., Nesti A., Simonelli F., Porcelli A.M., Torroni A., Carelli V. Peculiar combinations of individually non-pathogenic missense mitochondrial DNA variants cause low penetrance Leber’s hereditary optic neuropathy PLoS Genetics 2018 doi:10.1371/journal.pgen.1007210
Diquigiovanni C., Bergamini C., Evangelisti C., Isidori F., Vettori A., Tiso N., Argenton F., Costanzini A., Iommarini L., Anbunathan H., Pagotto U., Repaci A., Babbi G., Casadio R., Lenaz G., Rhoden K.J., Porcelli A.M., Fato R., Bowcock A., Seri M., Romeo G., Bonora E. Mutant MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer International Journal of Cancer 2018 doi:10.1002/ijc.31548
Iommarini L., Ghelli A., Leone G., Tropeano C.V., Kurelac I., Amato L.B., Gasparre G., Porcelli A.M. Mild phenotypes and proper supercomplex assembly in human cells carrying the homoplasmic m.15557G > A mutation in cytochrome b gene Human Mutation 2018 doi:10.1002/humu.23350
Iommarini L., Ghelli A., Tropeano C.V., Kurelac I., Leone G., Vidoni S., Lombes A., Zeviani M., Gasparre G., Porcelli A.M. Unravelling the effects of the mutation m.3571insC/MT-ND1 on respiratory complexes structural organization International Journal of Molecular Sciences 2018 doi:10.3390/ijms19030764
Leone G., Abla H., Gasparre G., Porcelli A.M., Iommarini L. The oncojanus paradigm of respiratory complex I Genes 2018 doi:10.3390/genes9050243
Perrone A.M., Girolimetti G., Procaccini M., Marchio L., Livi A., Borghese G., Porcelli A.M., De Iaco P., Gasparre G. Potential for mitochondrial DNA sequencing in the differential diagnosis of gynaecological malignancies International Journal of Molecular Sciences 2018 doi:10.3390/ijms19072048
Strobbe D., Caporali L., Iommarini L., Maresca A., Montopoli M., Martinuzzi A., Achilli A., Olivieri A., Torroni A., Carelli V., Ghelli A. Haplogroup J mitogenomes are the most sensitive to the pesticide rotenone: Relevance for human diseases Neurobiology of Disease 2018 doi:10.1016/j.nbd.2018.02.010
Trevisan T., Pendin D., Montagna A., Bova S., Ghelli A.M., Daga A. Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution Cell Reports 2018 doi:10.1016/j.celrep.2018.04.017
Tropeano C.V., Fiori J., Carelli V., Caporali L., Daldal F., Ghelli A.M., Rugolo M. Complex II phosphorylation is triggered by unbalanced redox homeostasis in cells lacking complex III Biochimica et Biophysica Acta - Bioenergetics 2018 doi:10.1016/j.bbabio.2017.12.003
De Luise M., Girolimetti G., Okere B., Porcelli A.M., Kurelac I., Gasparre G. Molecular and metabolic features of oncocytomas: Seeking the blueprints of indolent cancers Biochimica et Biophysica Acta - Bioenergetics 2017 doi:10.1016/j.bbabio.2017.01.009
Georg B., Ghelli A., Giordano C., Ross-Cisneros F.N., Sadun A.A., Carelli V., Hannibal J., La Morgia C. Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always
Mitochondrion 2017 doi:10.1016/j.mito.2017.04.003
Girolimetti G., Guerra F., Iommarini L., Kurelac I., Vergara D., Maffia M., Vidone M., Amato L.B., Leone G., Dusi S., Tiranti V., Perrone A.M., Bucci C., Porcelli A.M., Gasparre G. Platinum-induced mitochondrial DNA mutations confer lower sensitivity to paclitaxel by impairing tubulin cytoskeletal organization Human Molecular Genetics 2017 doi:10.1093/hmg/ddx186
Girolimetti G., Iaco P.D., Procaccini M., Panzacchi R., Kurelac I., Amato L.B., Dondi G., Caprara G., Ceccarelli C., Santini D., Porcelli A.M., Perrone A.M., Gasparre G. Mitochondrial dna sequencing demonstrates clonality of peritoneal implants of borderline ovarian tumors Molecular Cancer 2017 doi:10.1186/s12943-017-0614-y
Iommarini L., Ghelli A., Gasparre G., Porcelli A.M. Mitochondrial metabolism and energy sensing in tumor progression Biochimica et Biophysica Acta - Bioenergetics 2017 doi:10.1016/j.bbabio.2017.02.006
Iommarini L., Porcelli A.M., Gasparre G., Kurelac I. Non-canonical mechanisms regulating hypoxia-inducible factor 1 alpha in cancer Frontiers in Oncology 2017 doi:10.3389/fonc.2017.00286
Sansone P., Savini C., Kurelac I., Chang Q., Amato L.B., Strillacci A., Stepanova A., Iommarini L., Mastroleo C., Daly L., Galkin A., Thakur B.K., Soplop N., Uryu K., Hoshinob A., Norton L., Bonafé M., Cricca M., Gasparre G., Lyden D., Bromberg J. Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer Proceedings of the National Academy of Sciences of the United States of America 2017 doi:10.1073/pnas.1704862114
Lee J., Yi S., Kang Y.E., Chang J.Y., Kim J.T., Sul H.J., Kim J.O., Kim J.M., Kim J., Porcelli A.M., Kim K.S., Shong M. Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy Oncotarget 2016 doi:10.18632/oncotarget.12997
Porcelli A.M., Calvaruso M.A., Iommarini L., Kurelac I., Zuntini R., Ferrari S., Gasparre G. A unique combination of rare mitochondrial ribosomal RNA variants affects the kinetics of complex I assembly International Journal of Biochemistry and Cell Biology 2016 doi:10.1016/j.biocel.2016.04.007
Zaffagnini M., Fermani S., Calvaresi M., Orrù R., Iommarini L., Sparla F., Falini G., Bottoni A., Trost P. Tuning Cysteine Reactivity and Sulfenic Acid Stability by Protein Microenvironment in Glyceraldehyde-3-Phosphate Dehydrogenases of Arabidopsis thaliana Antioxidants and Redox Signaling 2016 doi:10.1089/ars.2015.6417
Giordano L., Deceglie S., D'Adamo P., Valentino M.L., La Morgia C., Fracasso F., Roberti M., Cappellari M., Petrosillo G., Ciaravolo S., Parente D., Giordano C., Maresca A., Iommarini L., Del Dotto V., Ghelli A.M., Salomao S.R., Berezovsky A., Belfort R., Jr., Sadun A.A., Carelli V., Loguercio Polosa P., Cantatore P. Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways Cell Death and Disease 2015 doi:10.1038/cddis.2015.364
Ham S., Lee M.H., Kim S.J., Park J.H., Lee s. E., Chang J.Y., Joung K.H., Kim T.Y., Kim J.M., Su H.J., Kweon G.R., Jo Y.S., Kim K.S., Shong Y.K., Gasparre G., Chung J.K., Porcelli A.M., Shong M., Lee J. Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors Carcinogenesis 2015 doi:10.1093/carcin/bgv122
Iommarini L., Peralta S., Torraco A., Diaz F. Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function Mitochondrion 2015 doi:10.1016/j.mito.2015.01.008
Kurelac I., de Biase D., Calabrese C., Ceccarelli C., Ng C.K.Y., Lim R., MacKay A., Weigelt B., Porcelli A.M., Reis-Filho J.S., Tallini G., Gasparre G. High-resolution genomic profiling of thyroid lesions uncovers preferential copy number gains affecting mitochondrial biogenesis loci in the oncocytic variants American Journal of Cancer Research 2015
Peralta S., Torraco A., Iommarini L., Diaz F. Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies Mitochondrion 2015 doi:10.1016/j.mito.2015.01.007
Pisano A., Preziuso C., Iommarini L., Perli E., Grazioli P., Campese A.F., Maresca A., Montopoli M., Masuelli L., Sadun A.A., d'Amati G., Carelli V., Ghelli A., Giordano C. Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy Human Molecular Genetics 2015 doi:10.1093/hmg/ddv396
Torraco A., Peralta S., Iommarini L., Diaz F. Mitochondrial diseases part I: Mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors Mitochondrion 2015 doi:10.1016/j.mito.2015.01.009
Vatrinet R., Iommarini L., Kurelac I., De Luise M., Gasparre G., Porcelli A.M. Targeting respiratory complex i to prevent the Warburg effect International Journal of Biochemistry and Cell Biology 2015 doi:10.1016/j.biocel.2015.01.017
Vidone M., Clima R., Santorsola M., Calabrese C., Girolimetti G., Kurelac I., Amato L.B., Iommarini L., Trevisan E., Leone M., Soffietti R., Morra I., Faccani G., Attimonelli M., Porcelli A.M., Gasparre G. A comprehensive characterization of mitochondrial DNA mutations in glioblastoma multiforme International Journal of Biochemistry and Cell Biology 2015 doi:10.1016/j.biocel.2015.01.027
Bergamini C., Angelini P., Rhoden K.J., Porcelli A.M., Fato R., Zuccheri G. A practical approach for the detection of DNA nanostructures in single live human cells by fluorescence microscopy Methods 2014 doi:10.1016/j.ymeth.2014.01.009
Carossa V., Ghelli A., Tropeano C.V., Valentino M.L., Iommarini L., Maresca A., Caporali L., La Morgia C., Liguori R., Barboni P., Carbonelli M., Rizzo G., Tonon C., Lodi R., Martinuzzi A., De Nardo V., Rugolo M., Ferretti L., Gandini F., Pala M., Achilli A., Olivieri A., Torroni A., Carelli V. A Novel in-Frame 18-bp Microdeletion in MT-CYB Causes a Multisystem Disorder with Prominent Exercise Intolerance Human Mutation 2014 doi:10.1002/humu.22596
Giordano C., Iommarini L., Giordano L., Maresca A., Pisano A., Valentino M.L., Caporali L., Liguori R., Deceglie S., Roberti M., Fanelli F., Fracasso F., Ross-Cisneros F.N., D'adamo P., Hudson G., Pyle A., Yu-Wai-Man P., Chinnery P.F., Zeviani M., Salomao S.R., Berezovsky A., Belfort R., Ventura D.F., Moraes M., Moraes Filho M., Barboni P., Sadun F., De Negri A., Sadun A.A., Tancredi A., Mancini M., D'amati G., Loguercio Polosa P., Cantatore P., Carelli V. Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy Brain 2014 doi:10.1093/brain/awt343
Iommarini L., Kurelac I., Capristo M., Calvaruso M.A., Giorgio V., Bergamini C., Ghelli A., Nanni P., De giovanni C., Carelli V., Fato R., Lollini P.L., Rugolo M., Gasparre G., Porcelli A.M. Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment Human Molecular Genetics 2014 doi:10.1093/hmg/ddt533
Musicco C., Cormio A., Calvaruso M.A., Iommarini L., Gasparre G., Porcelli A.M., Timperio A.M., Zolla L., Gadaleta M.N. Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex i Molecular BioSystems 2014 doi:10.1039/c3mb70542k
Vidone M., Alessandrini F., Marucci G., Farnedi A., De Biase D., Ricceri F., Calabrese C., Kurelac I., Porcelli A.M., Cricca M., Gasparre G. Evidence of association of human papillomavirus with prognosis worsening in glioblastoma multiforme Neuro-Oncology 2014 doi:10.1093/neuonc/not140
Calabrese C., Mangiulli M., Manzari C., Paluscio A.M., Caratozzolo M.F., Marzano F., Kurelac I., D'Erchia A.M., D'Elia D., Licciulli F., Liuni S., Picardi E., Attimonelli M., Gasparre G., Porcelli A.M., Pesole G., Sbisà E., Tullo A. A platform independent RNA-Seq protocol for the detection of transcriptome complexity BMC Genomics 2013 doi:10.1186/1471-2164-14-855
Caporali L., Ghelli A.M., Iommarini L., Maresca A., Valentino M.L., La Morgia C., Liguori R., Zanna C., Barboni P., De Nardo V., Martinuzzi A., Rizzo G., Tonon C., Lodi R., Calvaruso M.A., Cappelletti M., Porcelli A.M., Achilli A., Pala M., Torroni A., Carelli V. Cybrid studies establish the causal link between the mtDNA m.3890G>A/MT-ND1 mutation and optic atrophy with bilateral brainstem lesions Biochimica et Biophysica Acta - Molecular Basis of Disease 2013 doi:10.1016/j.bbadis.2012.12.002
Gasparre G., Porcelli A.M., Lenaz G., Romeo G. Relevance of mitochondrial genetics and metabolism in cancer development Cold Spring Harbor Perspectives in Biology 2013 doi:10.1101/cshperspect.a011411
Ghelli A., Tropeano C.V., Calvaruso M.A., Marchesini A., Iommarini L., Porcelli A.M., Zanna C., De Nardo V., Martinuzzi A., Wibrand F., Vissing J., Kurelac I., Gasparre G., Selamoglu N., Daldal F., Rugolo M. The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes Human Molecular Genetics 2013 doi:10.1093/hmg/ddt067
Iommarini L., Calvaruso M.A., Kurelac I., Gasparre G., Porcelli A.M. Complex i impairment in mitochondrial diseases and cancer: Parallel roads leading to different outcomes International Journal of Biochemistry and Cell Biology 2013 doi:10.1016/j.biocel.2012.05.016
Lanciano P., Khalfaoui-Hassani B., Selamoglu N., Ghelli A., Rugolo M., Daldal F. Molecular mechanisms of superoxide production by complex III: A bacterial versus human mitochondrial comparative case study Biochimica et Biophysica Acta - Bioenergetics 2013 doi:10.1016/j.bbabio.2013.03.009
Mancini C., Roncaglia P., Brussino A., Stevanin G., Lo Buono N., Krmac H., Maltecca F., Gazzano E., Bartoletti Stella A., Calvaruso M.A., Iommarini L., Cagnoli C., Forlani S., Le Ber I., Durr A., Brice A., Ghigo D., Casari G., Porcelli A.M., Funaro A., Gasparre G., Gustincich S., Brusco A. Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways BMC Medical Genomics 2013 doi:10.1186/1755-8794-6-22
Achilli A., Iommarini L., Olivieri A., Pala M., Hooshiar Kashani B., Reynier P., La Morgia C., Valentino M.L., Liguori R., Pizza F., Barboni P., Sadun F., de Negri A.M., Zeviani M., Dollfus H., Moulignier A., Ducos G., Orssaud C., Bonneau D., Procaccio V., Leo-Kottler B., Fauser S., Wissinger B., Amati-Bonneau P., Torroni A., Carelli V. Rare primary mitochondrial DNA mutations and probable synergistic variants in leber's hereditary optic neuropathy PLoS ONE 2012 doi:10.1371/journal.pone.0042242
Giorgio V., Petronilli V., Ghelli A., Carelli V., Rugolo M., Lenaz G., Bernardi P. The effects of idebenone on mitochondrial bioenergetics Biochimica et Biophysica Acta - Bioenergetics 2012 oi:10.1016/j.bbabio.2011.10.012
Iommarini L., Maresca A., Caporali L., Valentino M.L., Liguori R., Giordano C., Carelli V. Revisiting the issue of mitochondrial dna content in optic mitochondriopathies Neurology 2012 10.1212/WNL.0b013e31826d5f72
Petruzzella V., Carrozzo R., Calabrese C., Dell'aglio R., Trentadue R., Piredda R., Artuso L., Rizza T., Bianchi M., Porcelli A.M., Guerriero S., Gasparre G., Attimonelli M. Deep sequencing unearths Nuclear mitochondrial sequences under Leber's hereditary optic neuropathy-associated false heteroplasmic mitochondrial DNA variants Human Molecular Genetics 2012 10.1093/hmg/dds182
Carelli V., Schimpf S., Fuhrmann N., Valentino M.L., Zanna C., Iommarini L., Papke M., Schaich S., Tippmann S., Baumann B., Barboni P., Longanesi L., Rugolo M., Ghelli A., Alavi M.V., Youle R.J., Bucchi L., Carroccia R., Giannoccaro M.P., Tonon C., Lodi R., Cenacchi G., Montagna P., Liguori R., Wissinger B. A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16 Human Molecular Genetics 2011 10.1093/hmg/ddr071
Gasparre G., Kurelac I., Capristo M., Iommarini L., Ghelli A., Ceccarelli C., Nicoletti G., Nanni P., De Giovanni C., Scotlandi K., Betts C.M., Carelli V., Lollini P.L., Romeo G., Rugolo M., Porcelli A.M. A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an Oncojanus function Cancer Research 2011 10.1158/0008-5472.CAN-11-1042
Gasparre G., Romeo G., Rugolo M., Porcelli A.M. Learning from oncocytic tumors: Why choose inefficient mitochondria? Biochimica et Biophysica Acta - Bioenergetics 2011 10.1016/j.bbabio.2010.08.006
Giordano C., Montopoli M., Perli E., Orlandi M., Fantin M., Ross-Cisneros F.N., Caparrotta L., Martinuzzi A., Ragazzi E., Ghelli A., Sadun A.A., D'Amati G., Carelli V. Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy Brain 2011 10.1093/brain/awq276
Gonzalez-Halphen D., Ghelli A., Iommarini L., Carelli V., Esposti M.D. Mitochondrial complex I and cell death: A semi-automatic shotgun model Cell Death and Disease 2011 10.1038/cddis.2011.107
Capodicasa S., Fedi S., Porcelli A.M., Zannoni D. The microbial community dwelling on a biodeteriorated 16th century painting International Biodeterioration and Biodegradation 2010 10.1016/j.ibiod.2010.08.006
Porcelli A.M., Ghelli A., Ceccarelli C., Lang M., Cenacchi G., Capristo M., Pennisi L.F., Morra I., Ciccarelli E., Melcarne A., Bartoletti-Stella A., Salfi N., Tallini G., Martinuzzi A., Carelli V., Attimonelli M., Rugolo M., Romeo G., Gasparre G. The genetic and metabolic signature of oncocytic transformation implicates HIF1α destabilization Human Molecular Genetics 2010 10.1093/hmg/ddp566
Gasparre G., Iommarini L., Porcelli A.M., Lang M., Ferri G.G., Kurelac I., Zuntini R., Mariani E., Pennisi L.F., Pasquini E., Pasquinelli G., Ghelli A., Bonora E., Ceccarelli C., Rugolo M., Salfi N., Romeo G., Carelli V. An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells Human Mutation 2009 10.1002/humu.20870
Ghelli A.M., Porcelli A.M., Zanna C., Vidoni S., Mattioli S., Barbieri A., Iommarini L., Pala M., Achilli A., Torroni A., Rugolo M., Carelli V. The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity PLoS ONE 2009 10.1371/journal.pone.0007922
Porcelli A.M., Angelin A., Ghelli A., Mariani E., Martinuzzi A., Carelli V., Petronilli V., Bernardi P., Rugolo M. Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels Journal of Biological Chemistry 2009 10.1074/jbc.M807321200
Ramos C.V.F., Bellusci C., Savini G., Carbonelli M., Berezovsky A., Tamaki C., Cinoto R., Sacai P.Y., Moraes-Filho M.N., Miura H.M.P.P., Valentino M.L., Iommarini L., de Negri A.M., Sadun F., Cortelli P., Montagna P., Salomao S.R., Sadun A.A., Carelli V., Barboni P. Association of optic disc size with development and prognosis of Leber's hereditary optic neuropathy Investigative Ophthalmology and Visual Science 2009 10.1167/iovs.08-2695
Srivastava S., Diaz F., Iommarini L., Aure K., Lombes A., Moraes C.T. PGC-1α/β induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders Human Molecular Genetics 2009 10.1093/hmg/ddp093
Amati-Bonneau P., Valentino M.L., Reynier P., Gallardo M.E., Bornstein B., Boissière A., Campos Y., Rivera H., De La Aleja J.G., Carroccia R., Iommarini L., Labauge P., Figarella-Branger D., Marcorelles P., Furby A., Beauvais K., Letournel F., Liguori R., La Morgia C., Montagna P., Liguori M., Zanna C., Rugolo M., Cossarizza A., Wissinger B., Verny C., Schwarzenbacher R., Martín M.Á., Arenas J., Ayuso C., Garesse R., Lenaers G., Bonneau D., Carelli V. OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes Brain 2008 10.1093/brain/awm298
Ghelli A., Porcelli A.M., Zanna C., Martinuzzi A., Carelli V., Rugolo M. Protection against oxidant-induced apoptosis by exogenous glutathione in leber hereditary optic neuropathy cybrids Investigative Ophthalmology and Visual Science 2008 10.1167/iovs.07-0880
Morgia C.L., Achilli A., Iommarini L., Barboni P., Pala M., Olivieri A., Zanna C., Vidoni S., Tonon C., Lodi R., Vetrugno R., Mostacci B., Liguori R., Carroccia R., Montagna P., Rugolo M., Torroni A., Carelli V. Rare mtDNA variants in Leber hereditary optic neuropathy families with recurrence of myoclonus. Neurology 2008 10.1212/01.wnl.0000295505.74234.d0
Porcelli A.M., Ghelli A., Iommarini L., Mariani E., Hoque M., Zanna C., Gasparre G., Rugolo M. The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I Cellular and Molecular Life Sciences 2008 10.1007/s00018-008-8300-2
Zanna C., Ghelli A., Porcelli A.M., Karbowski M., Youle R.J., Schimpf S., Wissinger B., Pinti M., Cossarizza A., Vidoni S., Valentino M.L., Rugolo M., Carelli V. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion Brain 2008 10.1093/brain/awm335
Angeloni C., Maraldi T., Ghelli A., Rugolo M., Leoncini E., Hakim G., Hrelia S. Green tea modulates α1-adrenergic stimulated glucose transport in cultured rat cardiomyocytes Journal of Agricultural and Food Chemistry 2007 10.1021/jf071188+
Carelli V., La Morgia C., Iommarini L., Carroccia R., Mattiazzi M., Sangiorgi S., Farne' S., Maresca A., Foscarini B., Lanzi L., Amadori M., Bellan M., Valentino M.L. Mitochondrial optic neuropathies: How two genomes may kill the same cell type? Bioscience Reports 2007 10.1007/s10540-007-9045-0
Gasparre G., Porcelli A.M., Bonora E., Pennisi L.F., Toller M., Iommarini L., Ghelli A., Moretti M., Betts C.M., Martinelli G.N., Ceroni A.R., Curcio F., Carelli V., Rugolo M., Tallini G., Romeo G. Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors Proceedings of the National Academy of Sciences of the United States of America 2007 10.1073/pnas.0703056104
Bonora E., Porcelli A.M., Gasparre G., Biondi A., Ghelli A., Carelli V., Baracca A., Tallini G., Martinuzzi A., Lenaz G., Rugolo M., Romeo G. Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III Cancer Research 2006 10.1158/0008-5472.CAN-06-0171
Porcelli A.M., Ghelli A., Zanna C., Pinton P., Rizzuto R., Rugolo M. pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant Biochemical and Biophysical Research Communications 2005 10.1016/j.bbrc.2004.11.105
Zanna C., Ghelli A., Porcelli A.M., Martinuzzi A., Carelli V., Rugolo M. Caspase-independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G Apoptosis 2005 10.1007/s10495-005-0742-5
Carelli V., Rugolo M., Sgarbi G., Ghelli A., Zanna C., Baracca A., Lenaz G., Napoli E., Martinuzzi A., Solaini G. Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: A model of mitochondrial neurodegeneration Biochimica et Biophysica Acta - Bioenergetics 2004 10.1016/j.bbabio.2004.05.009
Porcelli A.M., Ghelli A., Zanna C., Valente P., Ferroni S., Rugolo M. Apoptosis induced by staurosporine in ECV304 cells requires cell shrinkage and upregulation of CI- conductance Cell Death and Differentiation 2004 10.1038/sj.cdd.4401396
Valentino M.L., Barboni P., Ghelli A., Bucchi L., Rengo C., Achilli A., Torroni A., Lugaresi A., Lodi R., Barbiroli B., Dotti M., Federico A., Baruzzi A., Carelli V. The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy Annals of Neurology 2004 10.1002/ana.20236
Ghelli A., Zanna C., Porcelli A.M., Schapira A.H.V., Martinuzzi A., Carelli V., Rugolo M. Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium Journal of Biological Chemistry 2003 10.1074/jbc.M210285200
Pettus B.J., Bielawski J., Porcelli A.M., Reames D.L., Johnson K.R., Morrow J., Chalfant C.E., Obeid L.M., Hannun Y.A. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α FASEB Journal 2003 10.1096/fj.02-1038com
Porcelli A.M., Ghelli A., Zanna C., Valente P., Ferroni S., Rugolo M. Staurosporine Induces Apoptotic Volume Decrease (AVD) in ECV304 Cells Annals of the New York Academy of Sciences 2003 10.1196/annals.1299.062
Zanna C., Ghelli A., Porcelli A.M., Carelli V., Martinuzzi A., Rugolo M. Apoptotic Cell Death of Cybrid Cells Bearing Leber's Hereditary Optic Neuropathy Mutations Is Caspase Independent Annals of the New York Academy of Sciences 2003 10.1196/annals.1299.037
Ghelli A., Porcelli A.M., Facchini A., Hrelia S., Flamigni F., Rugolo M. Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cδ Biochemical Journal 2002 10.1042/BJ20020264
Ghelli A., Porcelli A.M., Zanna C., Rugolo M. 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells Archives of Biochemistry and Biophysics 2002 10.1016/S0003-9861(02)00085-1
Porcelli A.M., Ghelli A., Hrelia S., Rugolo M. Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells Cellular Signalling 2002 10.1016/S0898-6568(01)00222-4
Porcelli A.M., Scotlandi K., Strammiello R., Gislimberti G., Baldini N., Rugolo M.A. Intracellular pH regulation in U-2 OS human osteosarcoma cells transfected with P-glycoprotein Biochimica et Biophysica Acta - Molecular Cell Research 2002 10.1016/S0167-4889(01)00173-2
Porcelli A.M., Pinton P., Ainscow E.K., Chiesa A., Rugolo M., Rutter G.A., Rizzuto R. Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH Methods in Cell Biology 2001 10.1016/s0091-679x(01)65021-0
Zegarra-Moran O., Porcelli A.M., Rugolo M. The phorbol ester PMA and cyclic AMP activate different Cl- and HCO3/- fluxes in C127 cells expressing CFTR Biochimica et Biophysica Acta - Molecular Basis of Disease 2001 10.1016/S0925-4439(00)00089-2
Orlati S., Porcelli A.M., Hrelia S., Van Brocklyn J.R., Spiegel S., Rugolo M. Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor Archives of Biochemistry and Biophysics 2000 10.1006/abbi.1999.1589
Andreani A., Rambaldi M., Leoni A., Morigi R., Locatelli A., Giorgi G., Lenaz G., Ghelli A., Degli Esposti M. 6-thienyl and 6-phenylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase European Journal of Medicinal Chemistry 1999 10.1016/S0223-5234(99)00203-2
Carelli V., Ghelli A., Bucchi L., Montagna P., De Negri A., Leuzzi V., Carducci C., Lenaz G., Lugaresi E., Degli Esposti M. Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with leber's hereditary optic neuropathy Annals of Neurology 1999 10.1002/1531-8249(199903)45:3<320::AID-ANA7>3.0.CO;2-L
Esposti M.D., Ghelli A. Ubiquinone and inhibitor sites in complex I: One, two or three? Biochemical Society Transactions 1999 10.1042/bst0270606
Porcelli A.M., Ghelli A., Mastrocola T., Rugolo M. Arachidonic acid release by ionomycin and phorbol ester is similar in C127 epithelial cells expressing wild-type or mutated (ΔF508) cystic fibrosis transmembrane conductance regulator Cellular and Molecular Life Sciences 1999 10.1007/s000180050015
Zegarra-Moran O., Rasola A., Rugolo M., Porcelli A.M., Rossi B., Galietta L.J.V. HIV-1 Nef expression inhibits the activity of a Ca2+-dependent K+ channel involved in the control of the resting potential in CEM lymphocytes Journal of Immunology 1999
Mastrocola T., Porcelli A.M., Rugolo M. Role of CFTR and anion exchanger in bicarbonate fluxes in C127 cell lines FEBS Letters 1998 10.1016/S0014-5793(98)01468-9
Orlati S., Porcelli A.M., Hrelia S., Lorenzini A., Rugolo M. Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells Biochemical Journal 1998 10.1042/bj3340641
Orlati S., Porcelli A.M., Hrelia S., Rugolo M. Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells Cell Calcium 1998 10.1016/S0143-4160(98)90095-1
Baracca A., Bucchi L., Ghelli A., Lenaz G. Protonophoric activity of NADH coenzyme Q reductase and ATP synthase in coupled submitochondrial particles from horse platelets Biochemical and Biophysical Research Communications 1997 10.1006/bbrc.1997.6807
Carelli V., Ghelli A., Ratta M., Bacchilega E., Sangiorgi S., Mancini R., Leuzzi V., Cortelli P., Montagna P., Lugaresi E., Degli Esposti M. Leber's hereditary optic neuropathy: Biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype Neurology 1997 10.1212/WNL.48.6.1623
Ghelli A., Benelli B., Esposti M.D. Measurement of the membrane potential generated by complex I in submitochondrial particles Journal of Biochemistry 1997 10.1093/oxfordjournals.jbchem.a021649
Ghelli A., Degli Esposti M., Carelli V., Lenaz G. Changes in mitochondrial complex I activity and coenzyme Q binding site in Leber's hereditary optic neuropathy (LHON) Molecular Aspects of Medicine 1997 10.1016/S0098-2997(97)00028-9
Helfenbaum L., Ngo A., Ghelli A., Linnane A.W., Esposti M.D. Proton pumping of mitochondrial complex I: Differential activation by analogs of ubiquinone Journal of Bioenergetics and Biomembranes 1997 10.1023/A:1022415906999
Degli Esposti M., Ngo A., Ghelli A., Benelli B., Carelli V., McLennan H., Linnane A.W. The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria Archives of Biochemistry and Biophysics 1996 10.1006/abbi.1996.0267
Degli Esposti M., Ngo A., McMullen G.L., Ghelli A., Sparla F., Benelli B., Ratta M., Linnane A.W. The specificity of mitochondrial complex I for ubiquinones Biochemical Journal 1996 10.1042/bj3130327
Ghelli A., Degli Esposti M., Carelli V., Lenaz G. Changes in mitochondrial complex I activity in Leber's hereditary optic neuropathy Italian Journal of Biochemistry 1996
Merlo Pich M., Bovina C., Formiggini G., Cometti G.G., Ghelli A., Parenti Castelli G., Genova M.L., Marchetti M., Semeraro S., Lenaz G. Inhibitor sensitivity of respiratory complex I in human platelets: A possible biomarker of ageing FEBS Letters 1996 10.1016/0014-5793(96)00037-3
Andreani A., Rambaldi M., Leoni A., Locatelli A., Ghelli A., Ratta M., Benelli B., Esposti M.D. Thienylimidazo[2,1-b]thiazoles as Inhibitors of Mitochondrial NADH Dehydrogenase Journal of Medicinal Chemistry 1995 10.1021/jm00007a006
Argese E., Bettiol C., Ghelli A., Todeschini R., Miana P. Submitochondrial particles as toxicity biosensors of chlorophenols Environmental Toxicology and Chemistry 1995 10.1002/etc.5620140302
Andreani A., Rambaldi M., Locatelli A., Leoni A., Ghelli A., Degli Esposti M. Thienylvinylindoles as inhibitors of mitochondrial NADH dehydrogenase Pharmaceutica Acta Helvetiae 1994 10.1016/0031-6865(94)90025-6
Degli Esposti M., Ghelli A., Ratta M., Cortes D., Estornell E. Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I) Biochemical Journal 1994 10.1042/bj3010161
Esposti M.D., Carelli V., Ghelli A., Ratta M., Crimi M., Sangiorgi S., Montagna P., Lenaz G., Lugaresi E., Cortelli P. Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy FEBS Letters 1994 10.1016/0014-5793(94)00971-6
Esposti M.D., Crimi M., Ghelli A. Natural variation in the potency and binding sites of mitochondrial quinone-like inhibitors Biochemical Society Transactions 1994 10.1042/bst0220209
Esposti M.D., Ghelli A. The mechanism of proton and electron transport in mitochondrial complex I BBA - Bioenergetics 1994 10.1016/0005-2728(94)90095-7
Esposti M.D., De Vries S., Crimi M., Ghelli A., Patarnello T., Meyer A. Mitochondrial cytochrome b: evolution and structure of the protein BBA - Bioenergetics 1993 10.1016/0005-2728(93)90197-N
Esposti M.D., Ghelli A., Crimi M., Estornell E., Fato R., Lenaz G. Complex I and complex III of mitochondria have common inhibitors acting as ubiquinone antagonists Biochemical and Biophysical Research Communications 1993 10.1006/bbrc.1993.1161
Esposti M.D., Ghelli A., Crimi M., Baracca A., Solaini G., Tron T., Meyer A. Cytochrome b of fish mitochondria is strongly resistant to funiculosin, a powerful inhibitor of respiration Archives of Biochemistry and Biophysics 1992 10.1016/0003-9861(92)90506-R
Ghelli A., Crimi M., Orsini S., Gradoni L., Zannotti M., Lenaz G., Degli Esposti M. Cytochrome b of protozoan mitochondria: Relationships between function and structure Comparative Biochemistry and Physiology -- Part B: Biochemistry and 1992 10.1016/0305-0491(92)90300-G
Mengoli M., Ghelli A., Chriqui D., Bagni N. Growth kinetics, polyamine pattern and biosynthesis in hairy root lines of Nicotiana tabacum Physiologia Plantarum 1992 10.1111/j.1399-3054.1992.tb04773.x
Esposti M.D., Ghelli A., Butler G., Roberti M., Mustich A., Cantatore P. The cytochrome b of the sea urchin Paracentrotus lividus is naturally resistant to myxothiazol and mucidin FEBS Letters
1990 10.1016/0014-5793(90)81384-Z
Degli Esposti M., Ghelli A., Luchetti R., Crimi M., Lenaz G. New approaches to the prediction of the folding of membrane proteins with redox function Italian Journal of Biochemistry 1989