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The object of our research are the planet microbiomes, as the life support system for the whole biosphere. Microbiomes are indeed responsible for oxygen production, global nutrient circulation, plant primary productivity, and animal and human health. This microbiome centrality for the planet health translates into multiple fields of application of our research, from human, animal and plant biology, where we explore the microbiome-host co-evolutionary trajectories and the impact on health and disease, to food production, resource circularization and environmental health, where natural microbiomes represent a promising source of sustainable solutions. Our primary goal is indeed to derive concrete microbiome-based applications for a better and more sustainable planet, targeting some of the 17 United Nation Sustainable Development Goals, such as good health and well-being, affordable and clean energy, sustainable cities and communities, climate action, life below water and life on land.