• Forte L.; Sarda S.; Torricelli P.; Combes C.; Brouillet F.; Marsan O.; Salamanna F.; Fini M.; Boanini E.; Bigi A., Multifunctionalization Modulates Hydroxyapatite Surface Interaction with Bisphosphonate: Antiosteoporotic and Antioxidative Stress Materials, ACS BIOMATERIALS SCIENCE & ENGINEERING 2019; 5:3429 - 3439

  • Rubini K.; Boanini E.; Bigi A., Role of aspartic and polyaspartic acid on the synthesis and hydrolysis of brushite, JOURNAL OF FUNCTIONAL BIOMATERIALS 2019;10: 1 - 12
  • Boanini E.; Gazzano M.; Nervi C.; Chierotti M.R.; Rubini K.; Gobetto R.; Bigi A., Strontium and zinc substitution in β-tricalcium phosphate: An X-ray diffraction, solid state NMR and ATR-FTIR study, JOURNAL OF FUNCTIONAL BIOMATERIALS 2019;10:1 - 15
  • Salamanna, F; Giavaresi, G; Parrilli, A; Torricelli, P; Boanini, E; Bigi, A; Fini, M, Antiresorptive properties of strontium substituted and alendronate functionalized hydroxyapatite nanocrystals in an ovariectomized rat spinal arthrodesis model, MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS 2019;95: 355 - 362
  • Salamanna F.; Giavaresi G.; Contartese D.; Bigi A.; Boanini E.; Parrilli A.; Lolli R.; Gasbarrini A.; Barbanti Brodano G.; Fini M., Effect of strontium substituted ß-TCP associated to mesenchymal stem cells from bone marrow and adipose tissue on spinal fusion in healthy and ovariectomized rat, JOURNAL OF CELLULAR PHYSIOLOGY 2019; 234: 20046 - 20056
  • Dolci L S, Panzavolta S, Torricelli P, Albertini B, Sicuro L, Fini M, Bigi A, Passerini N. Modulation of Alendronate release from a calcium phosphate bone cement: An in vitro osteoblast-osteoclast co-culture study. INTERNATIONAL JOURNAL OF PHARMACEUTICS 2019; 554: 245-255
  • Di Filippo  M F, Amadori S, Casolari S, Bigi A, Dolci L S,  Panzavolta S. Cylindrical Layered Bone Scaffolds with Anisotropic Mechanical Properties as Potential Drug Delivery Systems. MOLECULES 2019; 24:1931; 14 pages, doi:10.3390/molecules24101931



  • Forte L, Torricelli P, Boanini E, Bonvicini F, Lusvardi G, Gentilomi GA, Fini M, Bigi A. Biomimetic fabrication of antibacterial calcium phosphates mediated by polydopamine. JOURNAL OF INORGANIC BIOCHEMISTRY  2018;178:43-45. doi: 10.1016/j.jinorgbio.2017.10.004

  • Bigi A, Boanini E. Calcium phosphates as delivery systems for bisphosphonates. JOURNAL OF FUNCTIONAL BIOMATERIALS 2018; 9, 6 (18 pages). doi:10.3390/jfb9010006

  • Boanini E, Torricelli P, Bonvicini F, Cassani MC, Fini M, Gentilomi GA, Bigi A.  A new multifunctionalized material against multi-drug resistant bacteria and abnormal osteoclast activity. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2018; 127:120-129. doi: 10.1016/j.ejpb.2018.02.018

  • Boanini E, Torricelli P, Sima F, Axente E, Fini M, Mihailescu IN, Bigi A. Gradient coatings of strontium hydroxyapatite/ zinc beta-tricalcium phosphate as a tool to modulate osteoblast/osteoclast response. JOURNAL OF INORGANIC BIOCHEMISTRY 2018;183:1-8. doi:10.1016/j.jinorgbio.2018.02.024

  • Boanini E, Cassani MC, Rubini K, Boga C, Bigi A. (9R)-9-hydroxystearate-functionalized anticancer ceramics promote loading of Silver nanoparticles. NANOMATERIALS 2018; 8, 390 (9 pages); doi:10.3390/nano8060390
  • Dolci LS, Panzavolta S, Albertini B, Campisi B, Gandolfi M, Bigi A, Passerini N. Spray-congealed solid lipid microparticles as a new tool for the controlled release of bisphosphonates from a calcium phosphate bone cement. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2018;122: 6-16. doi: 10.1016/j.ejpb.2017.10.002
  • Dolci LS, Liguori A, Panzavolta S, Miserocchi A, Passerini N, Gherardi M, Colombo V, Bigi A, Albertini B. Non-equilibrium atmospheric pressure plasma as innovative method to crosslink and enhance mucoadhesion of econazole-loaded gelatin films for buccal drug delivery. COLLOIDS AND SURFACES B: BIOINTERFACES. 2018; 163: 73-82. doi:10.1016/j.colsurfb.2017.12.030
  • Della Bella E,  Parrilli A,  Bigi A, Panzavolta S, Amadori S, Giavaresi G, Martini L, Borsari V, Fini M. Osteoinductivity of nanostructured hydroxyapatite-functionalized gelatin modulated by human and endogenous mesenchymal stromal cells. c. J BIOMED MATER RES PART A: 2018; 106A: 914-923. doi: 10.1002/jbm.a.36295
  • Panzavolta S, Torricelli P, Casolari S, Parrilli A, Fini M, Bigi A. Strontium-Substituted Hydroxyapatite-Gelatin Biomimetic Scaffolds Modulate Bone Cell Response. MACROMOL. BIOSCI. 2018, 1800096 (10 pages) DOI: 10.1002/mabi.201800096



  • Forte L, Torricelli P, Boanini E, Gazzano M, Fini M, Bigi A. Antiresorptive And Anti-Angiogenetic Octacalcium Phosphate Functionalized With Bisphosphonates: An In Vitro Tri-Culture Study. ACTA BIOMATERIALIA 2017; 54:419-428.  doi: 10.1016/j.actbio.2017.02.040

  • Panzavolta S, Torricelli P, Casolari S, Parrilli A, Amadori S, Fini M, Bigi A. Gelatin Porous Scaffolds as Delivery Systems of Calcium Alendronate. MACROMOL BIOSCI, 2017;17:1600272 DOI: 10.1002/mabi.201600272  

  • Giacomini D, Torricelli P, Gentilomi GA, Boanini E, Gazzano M, Bonvicini F, Benetti E, Soldati R, Martelli G, Rubini K, Bigi A. Monocyclic b-lactams loaded on hydroxyapatite: new biomaterials with enhanced antibacterial activity against resistant strains. SCIENTIFIC REPORTS 2017;7:2712 (12 pages). doi:10.1038/s41598-017-02943-2

  • Bigi A, Boanini E. Functionalized biomimetic calcium phosphates for bone tissue repair. JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS 2017; 15,e-e. doi: 10.5301/jabfm.5000367
  • Forte L, Sarda S, Combes C, Brouillet F, Gazzano M, Marsan O, Boanini E, Bigi A. Hydroxyapatite functionalization to trigger adsorption and release of risedronate. COLLOIDS AND SURFACES B: BIOINTERFACES 2017; 160:493-499. doi: 10.1016/j.colsurfb.2017.09.055
  • Forte L, Torricelli P, Boanini E, Rubini K, Fini M, Bigi A. Quercetin and alendronate multi-functionalized materials as tools to hinder oxidative stress damage. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 2017;105:3293–3303. doi: 10.1002/jbm.a.36192



  • Boanini E, Panseri S, Arroyo F, Montesi M, Rubini K, Tampieri A, Covarrubias C, Bigi A (2016). Alendronate functionalized mesoporous bioactive glass nanospheres. MATERIALS vol. 9, p. 135 (12 pages).  doi: 10.3390/ma9030135.
  • Forte L, Torricelli P, Boanini E, Gazzano M, Rubini K, Fini M, Bigi A (2016). Antioxidant and bone repair properties of quercetin-functionalized hydroxyapatite: an in vitro osteoblast-osteoclast-endothelial cell co-culture study. ACTA BIOMATERIALIA vol. 32, p. 298-308. ISSN: 1742-7061, doi: 10.1016/j.actbio.2015.12.013
  • Boanini E, Torricelli P, Boga C, Micheletti G, Cassani MC, Fini M, Bigi A (2016). (9R)-9-hydroxystearate-functionalized hydroxyapatite as anti-proliferative and cytotoxic agent toward osteosarcoma cells. LANGMUIR vol. 32, p. 188-194. doi: 10.1021/acs.langmuir.5b03754
  • Gualandi C , Torricelli P,Panzavolta S,  Pagani S, Focarete M L, Bigi A. (2016)  An innovative co-axial system to electrospin in situ crosslinked gelatin nanofibers. BIOMED MATER vol.11, 025007
  • Panzavolta S, Gualandi C,  Fiorani A, Bracci B,  Focarete M L, Bigi A. (2016) Fast Coprecipitation of Calcium Phosphate Nanoparticles inside Gelatin Nanofibers by Tricoaxial Electrospinning. JOURNAL OF NANOMATERIALS, vol 2016, Article ID 4235235, 7 pages
  • Liguori A, Bigi A, Colombo V, Focarete ML, Gherardi M, Gualandi C, Oleari M C, Panzavolta S. Atmospheric pressure Non-Equilibrium Plasma as a Green Tool to Crosslink Gelatin Nanofibers. SCIENTIFIC REPORTS vol 6,38542 | DOI: 10.1038/srep38542 2016



  • E Boanini, P Torricelli, F Sima, E Axente, M Fini, I N Mihailescu, A Bigi (2015). Strontium and zoledronate hydroxyapatites graded composite coatings for bone prostheses. J COLLOID INTERF SCI  vol. 448, pp. 1-7. doi: 10.1016/j.jcis.2015.01.088
  • G Leone, MD Volpato, N Nelli, S Lamponi, E Boanini, A Bigi, A Magnani (2015). Continuous multi-layered composite hydrogel as osteochondral substitute. J BIOMED MATER RES A  vol. 103A, pp. 2521-2530. DOI: 10.1002/jbm.a.35389
  • S. Amadori, P.Torricelli, K. Rubini, M. Fini, S. Panzavolta, A. Bigi (2015). Effect of sterilization and crosslinking on gelatin films. J MATER SCI MATER MED vol. 26, pp. 1-9. doi: 10.1007/s10856-015-5396-4
  • E Boanini , P Torricelli, L Forte, S Pagani, N Mihailescu, C Ristoscu, IN Mihailescu, A Bigi (2015). Antiresorption implant coatings based on calcium alendronate and octacalcium phosphate deposited by matrix assisted pulsed laser evaporation. COLLOIDS AND SURFACES B: BIOINTERFACES vol. 136, p. 449-456.  doi: 10.1016/j.colsurfb.2015.09.044
  • S. Amadori, P.Torricelli, S.Panzavolta, A. Parrilli, M. Fini, A. Bigi (2015). Highly Porous Gelatin Reinforced 3D Scaffolds for Articular Cartilage Regeneration. MACROMOL. BIOSCI. vol. 15, pp. 941-952 DOI: 10.1002/mabi.201500014
  • S. Amadori, P.Torricelli, S. Panzavolta, A. Parrilli, M. Fini, A. Bigi (2015). Multi-Layered Scaffolds for Osteochondral Tissue Engineering: In Vitro Response of Co-Cultured Human Mesenchymal Stem Cells. MACROMOL. BIOSCI. 2015, DOI:  10.1002/mabi.201500165



  • E Boanini, P Torricelli, MC Cassani, GA Gentilomi, B Ballarin, K Rubini, F Bonvicini, A Bigi (2014) Cationic-anionic polyelectrolyte interaction as a tool to graft silver nanoparticles on hydroxyapatite crystals and prevent cytotoxicity. RSC ADVANCES vol. 4, pp. 645-652.
  • P Torricelli, M Gioffrè, A Fiorani, S Panzavolta, C Gualandi, M Fini, ML Focarete, A Bigi (2014) Co-electrospun gelatin-poly(L-lactic acid) scaffolds: Modulation of mechanical 6 properties and chondrocyte response as a function of composition. MATER. SCI. ENG. C vol. 36, pp. 130-138
  • IN Mihailescu, A Bigi, E Gyorgy, C Ristoscu, F Sima, E Toksoy Oner. Biomaterial Thin Films by Soft Pulsed Laser Technologies for Biomedical Applications. In Lasers in Materials Science. Castillejo, Marta; Ossi, Paolo M.; Zhigilei, Leonid (Eds.) 2014, Springer International Publishing, pp. 271-294.
  • S Panzavolta, M Gioffrè, B Bracci, K Rubini, A Bigi (2014) Montmorillonite Reinforced Type A Gelatin Nanocomposites. J. APPL. POLYM. SCI. vol. 131, pp. 40301 DOI: 10.1002/APP.40301
  • E Boanini, P Torricelli, M Gazzano, E Della Bella, M Fini, A Bigi (2014) Combined effect of strontium and zoledronate on hydroxyapatite structure and bone cell responses. BIOMATERIALS vol. 35, pp. 5619-5626
  • S Panzavolta, B Bracci, C Gualandi, ML Focarete, E Treossi, K Kouroupis-Agalou, K Rubini, F Bosia, L Brely, NM Pugno, V Palermo, A Bigi (2014) Structural reinforcement and failure analysis in composite nano fibers of graphene oxide and gelatin. CARBON vol. 78, pp. 566 –577
  • A Fiorani , C Gualandi , S Panseri, M Montesi, M Marcacci, ML Focarete, A Bigi (2014) Comparative performance of collagen nanofibers electrospun from different solvents and stabilized by different crosslinkers. J MATER SCI: MATER MED vol. 25, pp.2313–2321
  • S Focaroli, G Teti, V Salvatore, S Durante, M Mattioli Belmonte, R Giardino, A Mazzotti, A Bigi, M Falconi (2014) Chondrogenic Differentiation of Human Adipose Mesenchimal Stem Cells: Influence of a Biomimetic Gelatin Genipin Crosslinked Porous Scaffold. MICROSCOPY RESEARCH AND TECHNIQUE vol. 77, pp.928-934
  • S Durante, G Teti, V Salvatore, S Focaroli, M Mattioli-Belmonte, C Ferretti, A Bigi, R Giardino and M Falconi (2014) Matricellular Protein Expression and Cell Ultrastructure as Parameters to Test In Vitro Cytotoxicity of a Biomimetic Scaffold. J CYTOL HISTOL, vol. 5, pp.262. doi: 10.4172/2157-7099.1000262



  • E. Boanini, P. Torricelli, M. Gazzano, M. Fini, A. Bigi (2013) Crystalline Calcium Alendronate Obtained by Octacalcium Phosphate Digestion: a New Chance for Local Treatment of Bone Loss Diseases? ADVANCED MATERIALS vol. 25, pp. 4605-4611.
  • S. Panzavolta, P. Torricelli, S. Amadori, A. Parrilli, K. Rubini, E. della Bella, A. Bigi (2013) 3D Interconnected Porous Biomimetic Scaffolds: in vitro Cell Response. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH A, vol. 101, pp.3560-3570.
  • B. Bracci, S. Panzavolta, A. Bigi (2013) A New Simplified Calcifying Solution to Synthesize Calcium Phosphate Coatings. SURFACE AND COATINGS TECHNOLOGY, vol. 232, pp. 13-21.
  • V. Mariotti, M. Milella, E. Orsini, A. Trirè, A. Ruggeri, G. Fornaciari, S. Minozzi, D. Caramella, U. Albisinni, S. Gnudi, S. Durante, A. Todero, E. Boanini, K. Rubini, A. Bigi. M.G. Belcastro (2013) Osteobiography of a 19th Century Elderly Woman with Pertrochanteric Fracture and Osteoporosis: a Multidiciplinary Approach. COLLEGIUM ANTROPOLOGICUM, vol. 37, pp. 985-994.
  • G Teti, A Bigi, M Mattioli-Belmonte, R Giardino, M Fini, A Mazzotti and M Falconi. Morphological Evaluation of Adhesion and Proliferation of Osteoblast Like Cells Grown on Gelatin/Genipin Scaffold (JLS13031201). Journal of Life Sciences2013, 7(9), pp. 965-970



  • E. Boanini, M. Gazzano, A. Bigi. (2012). Time Course of Zoledronate Interaction with Hydroxyapatite Nanocrystals. JOURNAL OF PHYSICAL CHEMISTRY. C, NANOMATERIALS AND INTERFACES. vol. 116, pp. 15812 - 15818
  • E. Boanini, P. Torricelli, M. Fini, F. Sima, N. Serban, I.N. Mihailescu, A. Bigi. (2012). Magnesium and strontium doped octacalcium phosphate thin films by matrix assisted pulsed laser evaporation. JOURNAL OF INORGANIC BIOCHEMISTRY. vol. 107, pp. 65 - 72
  • E. Boanini, P. Torricelli, M. Gazzano, M. Fini, A. Bigi. (2012). The effect of alendronate doped calcium phosphates on bone cells activity. BONE. vol. 51, pp. 944 - 952
  • E. Boanini, P. Torricelli, M. Gazzano, M. Fini, A. Bigi. (2012). The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro. BIOMATERIALS. vol. 33, pp. 722 - 730
  • B Bracci, P Torricelli, S Panzavolta, K Rubini, M Fini, A Bigi. (2012). Gelatin-Modified Biomimetic Apatite Coatings. JOURNAL OF BIOMATERIALS AND NANOBIOTECHNOLOGY. vol. 3, pp. 154 - 162
  • B.Bracci, S.Panzavolta, A.Bigi, S.Prosperi, F.Bucciotti. (2012). Fast deposition of nanocrystalline hydroxyapatite into additive manufactured titanium porous structures. KEY ENGINEERING MATERIALS. vol. 493-494, pp. 458 - 461 ISSN: 1013-9826.
  • M. Gioffrè, P. Torricelli, S. Panzavolta, K. Rubini, A. Bigi. (2012). Role of pH on stability and mechanical properties of gelatin films. Journal of Bioactive and Compatible Polymers. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS. vol. 27, pp. 57 - 67
  • S. Panzavolta, B. Bracci, M. L. Focarete, C. Gualandi , A. Bigi. (2012). Fiber reinforcement of a biomimetic bone cement. JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. vol. 23, pp. 1363 - 1370



  • S. Panzavolta, M. Gioffrè, M. L. Focarete, C. Gualandi, L. Foroni, A. Bigi. (2011). Electrospun gelatin nanofibers: optimization of genipin crosslinking to preserve fiber morphology after exposure to water. ACTA BIOMATERIALIA. vol. 7, pp. 1702 - 1709
  • E. Boanini, A. Bigi. (2011). Biomimetic gelatin–octacalcium phosphate core–shell microspheres. JOURNAL OF COLLOID AND INTERFACE SCIENCE. vol. 362, pp. 594 - 599
  • E. Boanini, P. Torricelli, M. Fini, A. Bigi. (2011). Osteopenic bone cell response to strontium-substituted hydroxyapatite. JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. vol. 22, pp. 2079 - 2088 ISSN: 0957-4530.
  • S. Panzavolta, B. Bracci, K. Rubini, A. Bigi. (2011). Optimization of a biomimetic bone cement: Role of DCPD. JOURNAL OF INORGANIC BIOCHEMISTRY. vol. 105, pp. 1060



  • E. Boanini, K. Rubini, S. Panzavolta, A. Bigi. (2010). Chemico-physical characterization of gelatin films modified with oxidized alginate. ACTA BIOMATERIALIA. vol. 6, pp. 333 - 338
  • E. Boanini, M. Gazzano, A. Bigi. (2010). Ionic substitutions in calcium phosphates synthesized at low temperature. ACTA BIOMATERIALIA. vol. 6, pp. 1882 - 1894
  • E. Boanini, M. Gazzano, K. Rubini, A. Bigi. (2010). Collapsed Octacalcium Phosphate Stabilized by Ionic Substitutions. CRYSTAL GROWTH & DESIGN. vol. 10, pp. 3612 - 3617
  • E. Boanini, S. Panzavolta, K. Rubini, M. Gandolfi, A. Bigi. (2010). Effect of strontium and gelatin on the reactivity of a-tricalcium phosphate. ACTA BIOMATERIALIA. vol. 6, pp. 936 - 942
  • F. Comelli, A. Bigi, D. Vitalini, K. Rubini. (2010). Densities, Viscosities, Refractive Indices and Heat Capacities of Poly(Ethylene Glycol-ran-Propylene Glycol) + Esters of Carbonic Acid at (293.15 and 313.15) K and at Atmospheric Pressure. JOURNAL OF CHEMICAL AND ENGINEERING DATA. vol. 55, pp. 205 – 210
  • S. Panzavolta, P. Torricelli, B. Bracci, M. Fini, A. Bigi. (2010). Functionalization of biomimetic calcium phosphate bone cements with alendronate. JOURNAL OF INORGANIC BIOCHEMISTRY. vol. 104, pp. 1099 - 1106



  • A. Bigi, E. Boanini, C. Capuccini, M. Fini, I.N. Mihailescu, C. Ristoscu, F. Sima, P. Torricelli. (2009). Biofunctional alendronate–Hydroxyapatite thin films deposited by Matrix Assisted Pulsed Laser Evaporation. BIOMATERIALS. vol. 30, pp. 6168 - 6177
  • B. Badraoui, A. Aissa, A. Bigi, M. Debbabi, M. Gazzano. (2009). Synthesis and characterization of Sr(10_x)Cdx(PO4)6Y2 (Y = OH and F): A comparison of apatites containing two divalent cations. MATERIALS RESEARCH BULLETIN. vol. 44, pp. 522 - 530
  • Bracci B., Torricelli P., Panzavolta S., Boanini E., Giardino R., Bigi A. (2009). Effect of Mg2+, Sr2+, and Mn2+ on the chemico-physical and in vitro biological properties of calcium phosphate biomimetic coatings. JOURNAL OF INORGANIC BIOCHEMISTRY. vol. 103, pp. 1666 - 1674
  • Capuccini C., Torricelli P., Boanini E., Gazzano M., Giardino R., Bigi A. (2009). Interaction of Sr-doped hydroxyapatite nanocrystals with osteoclast and osteoblast-like cells. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A. vol. 89, pp. 594 - 600
  • I.N. Mihailescu, C Ristoscu, A Bigi, I Mayer. (2009). Advanced biomimetic implants based on nanostructured coatings synthesized by pulsed laser technologies. In Laser-Surface Interactions for New Materials Production: Tailoring Structure and Properties. (pp. 235 - 260). ISBN: 978-3-3642033067. BERLIN: Springer Verlag (GERMANY).
  • Panzavolta S., Fini M., Nicoletti A., Bracci B., Rubini K., Giardino R., Bigi A. (2009). Porous composite scaffolds based on partially hydrolyzed tricalcium phosphate and gelatin. ACTA BIOMATERIALIA. vol. 5, pp. 636 - 643
  • R. Francesconi, A. Bigi, D. Vitalini, K. Rubini, F. Comelli. (2009). Densities, Viscosities, Refractive Indices, and Heat Capacities of Four Poly(ethylene glycol)-Poly(propylene glycol)-Poly(ethylene glycol)-block-Copolymers + Dimethyl Sulfoxide at (298.15 and 313.15) K and at Atmospheric Pressure. JOURNAL OF CHEMICAL AND ENGINEERING DATA. vol. 54, pp. 956 - 961
  • S. Panzavolta,P. Torricelli, B. Bracci, M. Fini, A. Bigi. (2009). Alendronate and pamidronate calcium phosphate bone cements: Setting properties and in vitro response of osteoblast and osteoclast cells. JOURNAL OF INORGANIC BIOCHEMISTRY. vol. 103, pp. 101 – 106
  • A. Bigi. (2009). Materiali biomimetici : biomateriali a base di fosfati di calcio per la riparazione del tessuto osseo. NUOVA SECONDARIA. vol. 1, pp. 33 - 37 ISSN: 1828-4582