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Pubblicazioni
Questa sezione raccoglie i link agli articoli scientifici del nostro laboratorio.
2025
Cristina Cosentino, Rémy Klein, Véronique Menoud, Claudiane Guay, Elena Aiello, Stefano Auddino, Gianfranco Di Giuseppe, Gea Ciccarelli, Alessandra Galli, Francesco Alabiso, Eleonora Mangano, Flora Brozzi, Karim Bouzakri, Stefania D’Adamo, Silvia Cetrullo, Giuseppe Quero, Andrea Mari, Sergio Alfieri, Andrea Giaccari, Teresa Mezza, Francesco Dotta, Guido Sebastiani, Romano Regazzi 5’tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes bioRxiv 2025.07.22.665911; doi: https://doi.org/10.1101/2025.07.22.665911
Bissoli I, Alabiso F, Cosentino C, Seragnoli Chystyakova A, Ferré F, Alviano F, Marrazzo P, Pignatti C, Agnetti G, Regazzi R, Flamigni F, D'Adamo S, Cetrullo S. Modeling heart failure by induced pluripotent stem cell-derived organoids. Biochim Biophys Acta Mol Basis Dis. 2025 Aug;1871(6):167861. doi: 10.1016/j.bbadis.2025.167861. Epub 2025 Apr 18. PMID: 40254266.
Panichi V, Dolzani P, Cattini L, Alabiso F, Bissoli I, Cetrullo S, Columbaro M, Flamigni F, Arciola CR, Filardo G, Di Martino A, D'Adamo S, Borzì RM. Intrinsic amyloid deposition following proteostasis impairment in osteoarthritic chondrocytes: Insights and therapeutic approaches. Biochim Biophys Acta Mol Basis Dis. 2025 Aug;1871(6):167865. doi: 10.1016/j.bbadis.2025.167865. Epub 2025 Apr 26. PMID: 40294851.
2024
Rossi M, Pellegrino C, Rydzyk MM, Farruggia G, de Biase D, Cetrullo S, D'Adamo S, Bisi A, Blasi P, Malucelli E, Cappadone C, Gobbi S. Chalcones induce apoptosis, autophagy and reduce spreading in osteosarcoma 3D models. Biomed Pharmacother. 2024 Oct;179:117284. doi: 10.1016/j.biopha.2024.117284. Epub 2024 Aug 15. PMID: 39151310.
Panichi V, Bissoli I, D'Adamo S, Flamigni F, Cetrullo S, Borzì RM. NOTCH1: A Novel Player in the Molecular Crosstalk Underlying Articular Chondrocyte Protection by Oleuropein and Hydroxytyrosol. Int J Mol Sci. 2023 Mar 18;24(6):5830. doi: 10.3390/ijms24065830. PMID: 36982904; PMCID: PMC10058228.
Aleo SJ, Del Dotto V, Romagnoli M, Fiorini C, Capirossi G, Peron C, Maresca A, Caporali L, Capristo M, Tropeano CV, Zanna C, Ross-Cisneros FN, Sadun AA, Pignataro MG, Giordano C, Fasano C, Cavaliere A, Porcelli AM, Tioli G, Musiani F, Catania A, Lamperti C, Marzoli SB, De Negri A, Cascavilla ML, Battista M, Barboni P, Carbonelli M, Amore G, La Morgia C, Smirnov D, Vasilescu C, Farzeen A, Blickhaeuser B, Prokisch H, Priglinger C, Livonius B, Catarino CB, Klopstock T, Tiranti V, Carelli V, Ghelli AM. Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy. Cell Rep Med. 2024 Feb 20;5(2):101383. doi: 10.1016/j.xcrm.2023.101383. Epub 2024 Jan 24. PMID: 38272025; PMCID: PMC10897523.
2023
Panichi V, Bissoli I, D'Adamo S, Flamigni F, Cetrullo S, Borzì RM. NOTCH1: A Novel Player in the Molecular Crosstalk Underlying Articular Chondrocyte Protection by Oleuropein and Hydroxytyrosol. Int J Mol Sci. 2023 Mar 18;24(6):5830. doi: 10.3390/ijms24065830. PMID: 36982904; PMCID: PMC10058228.
Bissoli I, D'Adamo S, Pignatti C, Agnetti G, Flamigni F, Cetrullo S. Induced pluripotent stem cell-based models: Are we ready for that heart in a dish? Front Cell Dev Biol. 2023 Jan 19;11:1129263. doi: 10.3389/fcell.2023.1129263. PMID: 36743420; PMCID: PMC9892938.
Righetti R, Grillini S, Del Dotto V, Costanzini A, Liuzzi F, Zanna C, Sgarbi G, Solaini G, Baracca A. The Pro-Oncogenic Protein IF1 Promotes Proliferation of Anoxic Cancer Cells during Re-Oxygenation. Int J Mol Sci. 2023 Sep 27;24(19):14624. doi: 10.3390/ijms241914624. PMID: 37834071; PMCID: PMC10572598.
2022
Cavallo C, Merli G, Zini N, D'Adamo S, Cattini L, Guescini M, Grigolo B, Di Martino A, Santi S, Borzì RM, Filardo G. Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-κB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis. Stem Cells Int. 2022 Jul 18;2022:9376338. doi: 10.1155/2022/9376338. PMID: 35898656; PMCID: PMC9314187.
Olivotto E, Minguzzi M, D'Adamo S, Astolfi A, Santi S, Uguccioni M, Marcu KB, Borzì RM. Basal and IL-1β enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKKα and IKKβ NF-κB activating kinases. Sci Rep. 2021 Nov 4;11(1):21697. doi: 10.1038/s41598-021-01063-2. PMID: 34737366; PMCID: PMC8568921.
Danese A, Patergnani S, Maresca A, Peron C, Raimondi A, Caporali L, Marchi S, La Morgia C, Del Dotto V, Zanna C, Iannielli A, Segnali A, Di Meo I, Cavaliere A, Lebiedzinska-Arciszewska M, Wieckowski MR, Martinuzzi A, Moraes-Filho MN, Salomao SR, Berezovsky A, Belfort R Jr, Buser C, Ross-Cisneros FN, Sadun AA, Tacchetti C, Broccoli V, Giorgi C, Tiranti V, Carelli V, Pinton P. Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy. Cell Rep. 2022 Jul 19;40(3):111124. doi: 10.1016/j.celrep.2022.111124. PMID: 35858578; PMCID: PMC9314546.
2021
Olivotto E, Minguzzi M, D'Adamo S, Astolfi A, Santi S, Uguccioni M, Marcu KB, Borzì RM. Basal and IL-1β enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKKα and IKKβ NF-κB activating kinases. Sci Rep. 2021 Nov 4;11(1):21697. doi: 10.1038/s41598-021-01063-2. PMID: 34737366; PMCID: PMC8568921.
Cavallo C, Merli G, Borzì RM, Zini N, D'Adamo S, Guescini M, Grigolo B, Di Martino A, Santi S, Filardo G. Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-κB dependent inflammatory/catabolic environment of osteoarthritis. Sci Rep. 2021 Jan 13;11(1):1053. doi: 10.1038/s41598-020-80032-7. PMID: 33441764; PMCID: PMC7806716.
Minguzzi M, Panichi V, D'Adamo S, Cetrullo S, Cattini L, Flamigni F, Mariani E, Borzì RM. Pleiotropic Roles of NOTCH1 Signaling in the Loss of Maturational Arrest of Human Osteoarthritic Chondrocytes. Int J Mol Sci. 2021 Nov 5;22(21):12012. doi: 10.3390/ijms222112012. PMID: 34769441; PMCID: PMC8585104.
Neri S, Guidotti S, Bini C, Pelotti S, D'Adamo S, Minguzzi M, Platano D, Santi S, Mariani E, Cattini L, Borzì RM. Oxidative stress-induced DNA damage and repair in primary human osteoarthritis chondrocytes: focus on IKKα and the DNA Mismatch Repair System. Free Radic Biol Med. 2021 Apr;166:212-225. doi: 10.1016/j.freeradbiomed.2021.02.020. Epub 2021 Feb 23. PMID: 33636333.
Klionsky DJ, ....Cetrullo S, D'Adamo S,... Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751; PMCID: PMC7996087.
Rugolo M, Zanna C, Ghelli AM. Organization of the Respiratory Supercomplexes in Cells with Defective Complex III: Structural Features and Metabolic Consequences. Life (Basel). 2021 Apr 17;11(4):351. doi: 10.3390/life11040351. PMID: 33920624; PMCID: PMC8074069.
Aleo SJ, Del Dotto V, Fogazza M, Maresca A, Lodi T, Goffrini P, Ghelli A, Rugolo M, Carelli V, Baruffini E, Zanna C. Drug repositioning as a therapeutic strategy for neurodegenerations associated with OPA1 mutations. Hum Mol Genet. 2021 Jan 21;29(22):3631-3645. doi: 10.1093/hmg/ddaa244. PMID: 33231680; PMCID: PMC7823107.
Liparulo I, Bergamini C, Bortolus M, Calonghi N, Gasparre G, Kurelac I, Masin L, Rizzardi N, Rugolo M, Wang W, Aleo SJ, Kiwan A, Torri C, Zanna C, Fato R. Coenzyme Q biosynthesis inhibition induces HIF-1α stabilization and metabolic switch toward glycolysis. FEBS J. 2021 Mar;288(6):1956-1974. doi: 10.1111/febs.15561. Epub 2020 Sep 20. PMID: 32898935.
Selected Publications (2006–2020)
D'Adamo S, Cetrullo S, Guidotti S, Silvestri Y, Minguzzi M, Santi S, Cattini L, Filardo G, Flamigni F, Borzì RM. Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes. Free Radic Biol Med. 2020 Jun;153:159-172. doi: 10.1016/j.freeradbiomed.2020.03.029. Epub 2020 Apr 17. PMID: 32305648.
Cetrullo S, D'Adamo S, Panichi V, Borzì RM, Pignatti C, Flamigni F. Modulation of Fatty Acid-Related Genes in the Response of H9c2 Cardiac Cells to Palmitate and n-3 Polyunsaturated Fatty Acids. Cells. 2020 Feb 26;9(3):537. doi: 10.3390/cells9030537. PMID: 32110930; PMCID: PMC7140414.
D'Adamo S, Cetrullo S, Borzì RM, Flamigni F. Effect of oxidative stress and 3-hydroxytyrosol on DNA methylation levels of miR-9 promoters. J Cell Mol Med. 2019 Nov;23(11):7885-7889. doi: 10.1111/jcmm.14657. Epub 2019 Sep 8. PMID: 31496000; PMCID: PMC6815808.
D'Adamo S, Cetrullo S, Guidotti S, Borzì RM, Flamigni F. Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death. Osteoarthritis Cartilage. 2017 Apr;25(4):600-610. doi: 10.1016/j.joca.2016.11.014. Epub 2016 Dec 1. PMID: 27914878.
D'Adamo S, Alvarez-Garcia O, Muramatsu Y, Flamigni F, Lotz MK. MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins. Osteoarthritis Cartilage. 2016 Jun;24(6):1082-91. doi: 10.1016/j.joca.2016.01.005. Epub 2016 Jan 19. PMID: 26805019; PMCID: PMC4875787.
Cetrullo S, D'Adamo S, Guidotti S, Borzì RM, Flamigni F. Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms. Biochim Biophys Acta. 2016 Jun;1860(6):1181-91. doi: 10.1016/j.bbagen.2016.03.002. Epub 2016 Mar 3. PMID: 26947008.
Chao de la Barca JM, Fogazza M, Rugolo M, Chupin S, Del Dotto V, Ghelli AM, Carelli V, Simard G, Procaccio V, Bonneau D, Lenaers G, Reynier P, Zanna C. Metabolomics hallmarks OPA1 variants correlating with their in vitro phenotype and predicting clinical severity. Hum Mol Genet. 2020 May 28;29(8):1319-1329. doi: 10.1093/hmg/ddaa047. PMID: 32202296; PMCID: PMC7254852.
Maresca A, Del Dotto V, Capristo M, Scimonelli E, Tagliavini F, Morandi L, Tropeano CV, Caporali L, Mohamed S, Roberti M, Scandiffio L, Zaffagnini M, Rossi J, Cappelletti M, Musiani F, Contin M, Riva R, Liguori R, Pizza F, La Morgia C, Antelmi E, Loguercio Polosa P, Mignot E, Zanna C, Plazzi G, Carelli V. DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism. Hum Mol Genet. 2020 Jul 21;29(11):1864-1881. doi: 10.1093/hmg/ddaa014. PMID: 31984424; PMCID: PMC7372549.
Del Dotto V, Fogazza M, Musiani F, Maresca A, Aleo SJ, Caporali L, La Morgia C, Nolli C, Lodi T, Goffrini P, Chan D, Carelli V, Rugolo M, Baruffini E, Zanna C. Deciphering OPA1 mutations pathogenicity by combined analysis of human, mouse and yeast cell models. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3496-3514. doi: 10.1016/j.bbadis.2018.08.004. Epub 2018 Aug 4. PMID: 30293569.
Del Dotto V, Fogazza M, Lenaers G, Rugolo M, Carelli V, Zanna C. OPA1: How much do we know to approach therapy? Pharmacol Res. 2018 May;131:199-210. doi: 10.1016/j.phrs.2018.02.018. Epub 2018 Feb 15. PMID: 29454676.
Del Dotto V, Fogazza M, Carelli V, Rugolo M, Zanna C. Eight human OPA1 isoforms, long and short: What are they for? Biochim Biophys Acta Bioenerg. 2018 Apr;1859(4):263-269. doi: 10.1016/j.bbabio.2018.01.005. Epub 2018 Jan 31. PMID: 29382469.
Del Dotto V, Mishra P, Vidoni S, Fogazza M, Maresca A, Caporali L, McCaffery JM, Cappelletti M, Baruffini E, Lenaers G, Chan D, Rugolo M, Carelli V, Zanna C. OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions. Cell Rep. 2017 Jun 20;19(12):2557-2571. doi: 10.1016/j.celrep.2017.05.073. PMID: 28636943.
Abrams AJ, Hufnagel RB, Rebelo A, Zanna C, Patel N, Gonzalez MA, Campeanu IJ, Griffin LB, Groenewald S, Strickland AV, Tao F, Speziani F, Abreu L, Schüle R, Caporali L, La Morgia C, Maresca A, Liguori R, Lodi R, Ahmed ZM, Sund KL, Wang X, Krueger LA, Peng Y, Prada CE, Prows CA, Schorry EK, Antonellis A, Zimmerman HH, Abdul-Rahman OA, Yang Y, Downes SM, Prince J, Fontanesi F, Barrientos A, Németh AH, Carelli V, Huang T, Zuchner S, Dallman JE. Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder. Nat Genet. 2015 Aug;47(8):926-32. doi: 10.1038/ng.3354. Epub 2015 Jul 13. PMID: 26168012; PMCID: PMC4520737.
Maresca A, Zaffagnini M, Caporali L, Carelli V, Zanna C. DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated? Front Genet. 2015 Mar 12;6:90. doi: 10.3389/fgene.2015.00090. PMID: 25815005; PMCID: PMC4357308.
Zanna C, Ghelli A, Porcelli AM, Karbowski M, Youle RJ, Schimpf S, Wissinger B, Pinti M, Cossarizza A, Vidoni S, Valentino ML, Rugolo M, Carelli V. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. Brain. 2008 Feb;131(Pt 2):352-67. doi: 10.1093/brain/awm335. PMID: 18222991.
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