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Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS
A video summarizing the model of our last work published on Science Advances
Our recent scientific contributions
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A role for RNA polymerase II backtracking in cancer genome instability ?
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TDP1 mutation causing SCAN1 diseases affects repair of Top1ccs
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An immune signalling mechanism activated by Top1 poisons, often impaired in human SCLC tumours.
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Poorly-transcribed retrotrasposon can affect immune gene expression in human cancers
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An evaluation of current efforts aimed at the development of anticancer G4 ligands
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G4 stabilisation causes genome instability and immune gene activation in human osteosarcoma cells
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Recent review on G4-dependent genome instability in cancer
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Giulia Ricci, a former student, contributed to this paper on the mechanisms of Topoisomerase I DNA damage repair.
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Our PNAS paper on G4 and R-loops
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Top1 regulates R-loop homeostasis in a context-dependent manner suggesting a potential new role of Top1 in replication
CURRENT FINANCIAL SUPPORTS TO OUR PROJECTS
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We are supported by AIRC (Associazione Italiana per la Ricerca sul Cancro). We are grateful to people that donate to AIRC.
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FIRC-AIRC currently supports R.C. Duardo, a post-doc fellow in the lab.
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MUR PRIN program also supports our research projects
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We receive funds from PNRR under the CN - mRNA and PE06 - HEAL ITALIA.