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DNA topoisomerases, non-B DNA structures and DNA repair factors
Laboratory of Cancer Genome Instability
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Congratulations to the new graduates!
G-loops can form behind an elongating RNA polymerase II
G4-mediated micronuclei activate immune genes in cancer cells
At a recent lab meeting
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RECENT SCIENTIFIC ADVANCES
G4 stabilisation causes genome instability and immune gene activation in human osteosarcoma cells
Recent review on G4-dependent genome instability in cancer
Giulia Ricci, a former student, contributed to this paper on the mechanisms of Topoisomerase I DNA damage repair.
Our PNAS paper on G4 and R-loops
Top1 regulates R-loop homeostasis in a context-dependent manner suggesting a potential new role of Top1 in replication
CURRENT FINANCIAL SUPPORTS TO OUR PROJECTS
We are supported by AIRC (Associazione Italiana per la Ricerca sul Cancro). We are grateful to people that donate the money to AIRC.
FIRC-AIRC currently supports our post-doc fellow, R.C. Duardo.
MUR PRIN program also supports our research projects
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