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Congratulations to the new graduates!
G-loops can form behind an elongating RNA polymerase II
G4-mediated micronuclei activate immune genes in cancer cells
At a recent lab meeting

Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS

A video summarizing the model of our last work published on Science Advances

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Our recent scientific contributions

A role for RNA polymerase II backtracking in cancer genome instability ?
TDP1 mutation causing SCAN1 diseases affects repair of Top1ccs
An immune signalling mechanism activated by Top1 poisons, often impaired in human SCLC tumours.
Poorly-transcribed retrotrasposon can affect immune gene expression in human cancers
An evaluation of current efforts aimed at the development of anticancer G4 ligands
G4 stabilisation causes genome instability and immune gene activation in human osteosarcoma cells
Recent review on G4-dependent genome instability in cancer
Giulia Ricci, a former student, contributed to this paper on the mechanisms of Topoisomerase I DNA damage repair.
Our PNAS paper on G4 and R-loops
Top1 regulates R-loop homeostasis in a context-dependent manner suggesting a potential new role of Top1 in replication

CURRENT FINANCIAL SUPPORTS TO OUR PROJECTS