Mobility experience with a research focus
PhD sandwich
Department of Life Sciences
The project will be mainly focused on the study of complement system in the tumor microenvironment of malignant pleural mesothelioma (MPM), a rare and aggressive tumour of the pleura. In fact, ever-growing evidence shed light on the involvement of immune contexture in controlling tumour progression and, in particular, on the controversial role of complement system in cancer. In the current project, we aim at performing preliminary bioinformatics analysis and further immunohistochemical analysis on MPM tissue sections in order to characterize the expression and localization of different complement components, evaluating their production by tumor cells and other immune and non-malignant host cell types within MPM microenvironment. Moreover, different MPM cell lines and primary cells will be analyzed by Real-Time qPCR, flow cytometry and Western blot to determine complement component production at the cellular level and to drive further functional assays.
English
PhD sandwich: 6-12