Targeting metabolic signaling cross-talk between cancer cells and the tumor microenvironment in head and neck cancer
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Date: 19 NOVEMBER 2025 from 17:30 to 19:00
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Event location: Aula III via Francesco Selmi 2 - Bologna, Piano Terra.
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Type: Lectures
Speaker
ISA Visiting Fellow - Dhruv Kumar
Professor and Head UPES, Dehradun - India
ATTENDANCE
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in presence - book your seat
Book your seat within November 19, 12 p.m. The places will be assigned on “first come first served” basis.
The accessibility of the building is barrier-free, with pathway from the side entrance with building slide to the classroom located on the ground floor. Also available to persons with disabilities is a single-seat anthropometric bench with variable elevation and tilt positioned near the desk.
Targeting metabolic signaling cross-talk between cancer cells and the tumor microenvironment offers promising therapeutic strategies for head and neck cancer. Cancer cells exhibit heightened glycolysis, rapidly consuming glucose and releasing lactic acid into the microenvironment. This lactic acid fuels mitochondrial respiration in cancer-associated fibroblasts, further supporting tumor progression. c-Met/HGF signaling in cancer cells drives glycolysis, while FGFR/FGF2 signaling in fibroblasts enhances mitochondrial activity. Therapeutically inhibiting these interconnected pathways has the potential to disrupt tumor-supportive metabolism, suppress tumor growth, and lead to the development of effective treatments.