How do we sense temperature? The role of TRP ion channels in mechanisms of temperature and pain sensation studied via computer simulation
An overview of current knowledge
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Date: 14 MAY 2024 from 17:30 to 19:00
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Event location: Sala Rossa, Palazzo Marchesini, Via Marsala, 26 - Bologna - In presence and online event
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Type: Lectures
Transient receptor potential (TRP) ion channels constitute a notable family of cation channels involved in the ability of organisms to detect noxious mechanical, thermal and chemical stimuli. One of the most experimentally studied agonist of TRP channels is capsaicin, which is responsible for the burning sensation produced when chili pepper is in contact with organic tissues. Understanding how TRP channels are regulated by capsaicin and other natural products is essential to high impact pharmacological applications, particularly those related to pain treatment. By selected examples from the work we have carried out, I will provide an overview of the current knowledge we have about activation, permeation and selectivity of one of the so-called human molecular thermometers.
DO YOU WANT TO ATTEND THIS lecture?
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Sala Rossa, Palazzo Marchesini, Via Marsala, 26 - Bologna
If you prefer to attend this lecture in presence, you should write to segreteria.isa@unibo.it within May 14, 12 p.m. and book your place. The places will be assigned on “first come first served” basis.
Please note that the building is not equipped so as to facilitate access for wheelchair users or people with mobility issues.
PhD students and researchers who are interested may request an attendance certificate by writing to segreteria.isa@unibo.it specifying their birthplace and date of birth.
The delivery of the attendance certificate requires the attendance of at least 70% of the lecture.