Gliomas, particularly glioblastomas, represent the most common and aggressive form of malignant tumors of the Central Nervous System. These tumors are characterized by significant heterogeneity and resistance to currently available treatments. Our project is dedicated to exploring the dynamics of interaction at both the glioma cell level and the tumor microenvironment through three main research lines:
- Study of phospholipase modulation in glioblastoma: we have identified the phospholipases PLCβ1 and PLCγ1 as novel modulators of glioblastoma aggressiveness through in vitro models. These studies suggest that the expression of these phospholipases plays a role in tumor cell proliferation, migration, and survival, opening new perspectives for targeted treatments.
- Study of the role of nuclear lamins in glioblastoma: using in vitro models, we are investigating how nuclear envelope proteins - particularly lamin A/C - affect glioblastoma aggressiveness, migration, and proliferation, with the goal of identifying new therapeutic strategies.
- Study of glioma secretome and interaction with the microenvironment: we are developing and refining an innovative protocol for extracting the secretome directly from glioma patient tumor tissues. This protocol allows for a more precise exploration of how tumors communicate with the microenvironment to promote their own growth, paving the way for a deeper understanding of tumor microenvironment dynamics.
Our objective goes beyond merely understanding the mechanisms driving glioma aggressiveness and resistance. We aspire to improve the treatment of these tumors by providing valuable insights for the development of new therapeutic strategies that not only slow disease progression but also significantly enhance patients' quality of life and clinical outcomes.
