Stem Cells and Myelodysplastic Neoplasms (MDS)

Our research, conducted in collaboration with various Italian and international hematology centers, integrates molecular, cellular, and therapeutic studies. The goal is to deepen our understanding of the mechanisms underlying leukemia progression and to enhance the effectiveness of pharmacological treatments. Our main areas of interest include:

1. The study of signal transduction pathways, with a particular focus on inositide-dependent mechanisms, which are crucial for cellular regulation.
2. The analysis of the bone marrow microenvironment to investigate the interactions between tumor cells and their surroundings. Specifically, we are also conducting experiments to validate mesenchymal cells derived from dental pulp as an ethical alternative model to bone marrow cells.
3. The investigation of the mechanisms of action of combination therapy with azacitidine and venetoclax, with a particular focus on the biological processes influencing treatment efficacy and the emerging resistance mechanisms in patients.
4. The identification and characterization of specific microRNAs involved in the therapeutic response.