Project partners

“La Sapienza” University of Rome

The School of Aerospace Engineering of the "La Sapienza" University of Rome is resposible for the coordination and supervision of the project. By virtue of its natural vocation, the research experiences of the School of Aerospace Engineering fit almost exclusively in the field of space experimentation from the study of space missions to the development of new hardware and software components up to the creation of complete satellite systems. The research activity of the School of Aerospace Engineering includes numerous scientific collaborations with national and international research groups and companies engaged in scientific research and technological activities in the Space field, in particular: Telespazio, Thales Alenia Space, Kayser Italia Srl, Gauss Srl, National Institute of Astrophysics, National Research Council, University of Bologna, Polytechnic of Milan. These collaborations are demonstrated by joint participation in research projects and scientific publications. The School has several experience in development of lab-on-chip device for space applications through the participation in several projects supported by ASI like PLEIADES, AstroBio CubeSat and APHRODITE. 

Role in the project

  •  Coordination and supervision of all the project activities.
  • Set up and manage an effective Integrated Design Model (IDM) to manage all the concurrent engineering activities of the project.
  • Carry out the overall administrative and financial management of the project.
  • Management of the contract with the European Commission and the Consortium Agreement.
  • Monitor quality and timing of project deliverables.
  • Assess potential risks and mitigate their impact.
  • Establish effective communication procedures.

University of Twente 

The UniversityofTwente is a public technical university founded in 1961 and located in Enschede, the Netherlands. The university has been placed in the top 170 universities in the world by multiple central ranking tables and was ranked the best technical university in The Netherlands by Keuzegids Universiteiten, the most significant national university ranking. The UT collaborates with Delft University of Technology, Eindhoven University of Technology and the Wageningen University and Research Centre in the 4TUFederation and is also a partner in the EuropeanConsortiumofInnovative Universities (ECIU). The university hosts ca. 13,000 students and 3,800 employees, and annually hands out ca. 200 PhD degrees. The University of Twente connects technology, science and engineering with social sciences. The education and research are organised within 5 faculties. This project will be hosted by the Faculty of ScienceandTechnology, and represented by the MesoscaleChemicalSystems group. This group carries out applied research of a multidisciplinary nature, with a focus on mesoscale phenomena, i.e. the scale ranging from a millimeter down to a few nanometers. The core activity of our group is the design, modelling, fabrication and testing of 3dimensional micro and nano structures and their integration in electronic, mechanical, (bio)chemical or medical miniaturized components and systems. Fabrication processes are mostly carried out in the MESA+NanoLab, with its 1200 m2 cleanroom and analysis facilities.  

Role in the project 

  • Participation to concurrent engineering activities for the design and testing of the lab-on-chip micro-incubator device and breadboard analytical device. 
  • High-level design of the lab-on-chip device according to the system-level constraints and to the requirements of the biological experimental part. 
  • Detailed microfluidic network design, including finite element simulations and measurements on partial prototypes, design of optimal layout and manufacturing process flows, and fabrication of the microfluidic network for gas and liquid supply to several independent micro-incubation chambers. 
  • Integration of microfluidics and thin-film components in a single device, and its validation.  
  • Participation in Coordination and Communication, Dissemination and Exploitation (CD&E) activities. 

Kayser Italia S.r.l.

Kayser Italia S.r.l. is a privately owned aerospace system engineering company located in Livorno, Tuscany. With over 30 years of experience, the company specializes in the design, development, manufacture, and testing of systems and components for scientific and technological research activities on board of space platforms. The staff consists of more than 70 highly skilled engineers with expertise in electronics, mechanics, thermodynamics, physics, computer science, optics, and molecular biology. Kayser Italia has contributed to more than 50 space missions with over 100 payloads, working as prime or sub-contractor for the European and the Italian Space Agency, NASA and others. The company's main goal is to consolidate its leadership position in Europe in the development of payloads and microgravity experiments. Kayser Italia supports partnerships and programs with universities and research institutes.

Role in the project

  • Define and assemble the breadboard system, incorporating all the subsystems into the analytical device.
  • Develop the fluidic actuation subsystem, including its electronics.
  • Develop the mechanical ancillary subsystem.
  • Design and implement the control electronics and the control system.
  • Develop the user interface (UI).
  • Test the breadboard analytical device.
University of Bologna logo

University of Bologna

The University of Bologna takes part into a number of international networks and associations and actively participates in several initiatives connected with Horizon Europe. According to the latest ranking by Censis, the Alma Mater ranks first among Italian universities with more than 40,000 students for the thirteenth consecutive year. At UniBo, research activities are promoted, coordinated and supported by the 31 Departments. This project will be hosted by the Department of Chemistry “Giacomo Ciamician” which, since 2013, has firmly held its position as the best chemistry department in Italy. In the project, the Department is represented by the Bioanalytical Chemistry group, which consists of analytical chemists, experts in the development of bioanalytical methods and biosensors based on bio- and chemiluminescence (BL/CL) detection. The group has a mature experience in the development of CL-based miniaturized analytical devices for life science applications in space environment, acquired through the participation to various projects supported by the Italian Space Agency (IN SITU, PLEIADES, AstroBio CubeSat, APHRODITE) and is well-experienced in the development of genetically engineered whole-cell BL biosensors.

Role in the project

  • Participation to concurrent engineering activities for the design and testing of the lab-on-chip micro-incubator device and breadboard analytical device.
  • Production of bioluminescent biosensors based on eukaryotic cell lines (S. cerevisiae and 3D spheroids of HEK-293 cells) genetically engineered in order to emit bioluminescence upon cytotoxicity, genotoxicity, or oxidative damage events elicited by exposure to the space environment.
  • Development of strategies to obtain robust, air-dried yeast biosensors that could be metabolically activated when in orbit, as well as to maintain the viability of HEK-293 cells for a timeframe suitable for space experiments.
  • Validation of the biosensors’ analytical performance under simulated microgravity and ionizing radiation.
  • Coordination of project Communication, Dissemination and Exploitation (CD&E) activities to reach the widest audience, composed by stakeholders as well as general public and at exploiting the foreground generated within the project.

University of Rome Tor Vergata

The University of Rome Tor Vergata develops thematic and inter-disciplinary research programmes with first-class institutions (at national and international level) and the best universities worldwide. According to the QR 2023 ranking Tor Vergata is among the best universities in 18 subjects, including mathematics, classics and ancient history, physics and astronomy. This project will be hosted by the Department of Biology and it will be represented by the group of Astrobiology and Molecular Biology of Cyanobacteria which consist in expert on the effects of space exposure of cyanobacteria and on the monitoring their behavior under stress conditions. This know-how was acquired through various projects supported by the Italian Space Agency, like BOSS_cyano, BIOMEX_cyano, BIOSIGN_cyano, Life in Space and ReBUS.

Role in the project

  • Participation to concurrent engineering activities for the design and testing of the lab-on-chip micro-incubator device and breadboard analytical device.
  • Production of bioluminescent biosensors based on bacterial and cyanobacterial strains (Escherichia coli and Chroococcidiopsis sp.) genetically engineered in order to emit bioluminescence upon the oxidative damage produced duirng the exposure to the space environment.
  • Development of strategies to obtain robust, air-dried biosensors that could be metabolically activated when in orbit, as well as to maintain the viability during the space experiments.
  • Validation of the biosensors' analytical performance under simulated microgravity and ionizing radiation

Karlsruher Institut für Technologie

The Karlsruher Institut für Technologie is one of the leading German research institutions with a focus on engineering and the natural sciences as well as a university of excellence within the German excellence strategy. KIT was founded in 2009 by merging its precursor institutions University of Karlsruhe and the Karlsruhe Research Center. Research, teaching, and innovation are the core tasks of KIT, where more than 5,500 scientists cooperate in a broad range of disciplines in natural and engineering sciences, economics, the humanities, and social sciences.

The project will be hosted by the Institute of Data Processing and Electronics (IPE) and the Helmholtz research program “Detector Technologies and Systems”. We conceive and develop cutting-edge detector technologies and systems to keep KITs research activities at the forefront of scientific discovery, to exploit the scientific potential of our current and future facilities, and to explore novel detection methods that promise to open entirely new research directions. We will in particular strive to push the physical limits of space, energy, and time resolution, both in principle and in concrete systems, ready for experiment. In addition, we will develop innovative detector and data acquisition concepts to cope with the extreme data rates and adverse environmental constraints that are typical for experiments in large-scale research.

Role in the project

  • Participation to concurrent engineering activities for the design and testing of the lab-on-chip micro-incubator device and breadboard analytical device.
  • Identification and procurement of the radiation sensor for the dosimeter.
  • Development of the dosimeter readout card.
  • Dosimeter test and characterization.
  • Integration of the dosimeter in the breadboard and validation.
  • Participation in coordination and communication, dissemination and exploitation activities.