The vascular component in SD: a new pathophysiological and therapeutic target

Inspired by genetic models of chronic intestinal pseudo-obstruction (CIPO), this project aims to comprehensively characterize gastrointestinal vascularization in patients with idiopathic severe dysmotility (SD). The characterization is carried out at multiple levels:

1. Genetic aspect: A search for new genes associated with the disease is conducted to identify potential genetic determinants.
2. Molecular aspect: Transcriptomic analysis is used to explore common molecular programs involved, with a specific focus on angiogenic factor signaling, analyzed both in ex vivo tissues and cellular models.
3. Morphological aspect: Microanatomical alterations of the vascular component are studied in paraffin-embedded tissues, mapping potential key players identified through molecular analyses.

The ultimate goal of this project is to identify a primum movens that could provide a clearer understanding of SD pathophysiology and guide the development of new diagnostic and therapeutic strategies